COLIGETZ-4.5VIAL 1VIAL

About

Coligetz-4.5VIAL contains colistin (polymyxin E), a polymyxin antibiotic administered intravenously, primarily used as a last-resort treatment for severe infections caused by multi-drug resistant (MDR) Gram-negative bacteria. Colistin exerts its bactericidal effect by disrupting the integrity of the bacterial cell membrane, leading to leakage of intracellular contents and subsequent cell death. It is particularly effective against challenging pathogens such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, which are often resistant to many other antibiotic classes.

Due to its potential for significant nephrotoxicity and neurotoxicity, Coligetz-4.5VIAL is typically reserved for patients with limited treatment options. It is crucial to carefully weigh the benefits against the risks and to closely monitor renal function and neurological status throughout the course of therapy. Dose adjustments are essential in patients with impaired kidney function to minimize adverse effects while maintaining therapeutic efficacy.

Uses

• Treatment of severe infections caused by multi-drug resistant Gram-negative bacteria.
• Management of ventilator-associated pneumonia (VAP).
• Therapy for hospital-acquired pneumonia (HAP).
• Treatment of complicated urinary tract infections (cUTI).

Directions For Use

Administer intravenously as directed by a healthcare professional. Dosage and duration depend on the infection's severity and patient response, with careful consideration of renal function.

Benefits

• Effective against highly resistant Gram-negative pathogens.
• Crucial for treating multi-drug resistant (MDR) infections.
• Provides an alternative when other antibiotics fail.
• Can be used in combination therapy for synergistic effects.
• Available in IV and inhaled forms for specific indications.
• Life-saving for patients with limited treatment options.

Side Effects

• Nephrotoxicity (kidney damage)
• Neurotoxicity (dizziness, paresthesia)
• Acute respiratory failure
• Allergic reactions
• Injection site reactions
• Fever
• Rash
• C. difficile infection
• Muscle weakness
• Vertigo
• Facial paresthesia
• Apnea

Safety Measures

• Alcohol - No direct interaction with alcohol. However, alcohol consumption may exacerbate general malaise associated with severe infections.
• Pregnancy - Use during pregnancy should only be considered if the potential benefit outweighs the potential risk to the fetus. Consult a physician before use.
• Breastfeeding - Small amounts may pass into breast milk. Use with caution and monitor the infant for adverse effects. Consult a healthcare provider.
• Liver - Use with caution in patients with hepatic impairment, although colistin is primarily eliminated renally. Liver function should be monitored.
• Kidney - Significant dose adjustments are required for patients with renal impairment due to high risk of nephrotoxicity. Close monitoring of kidney function is essential.
• Lung - Caution is advised in patients with pre-existing lung conditions, especially if administered via inhalation, due to potential for bronchospasm. Monitor respiratory status closely.

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