GUFICOL 4.5 ING 1VIAL

About

Guficol 4.5 Injection, a combination of piperacillin and tazobactam, is a potent broad-spectrum antibiotic used to treat serious bacterial infections. Piperacillin is an extended-spectrum penicillin that inhibits bacterial cell wall synthesis, while tazobactam is a beta-lactamase inhibitor that protects piperacillin from degradation by bacterial enzymes, thereby extending its antibacterial activity. This combination is effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria, including many resistant strains.

It is particularly valuable in treating infections such as complicated intra-abdominal infections, pelvic inflammatory disease, community-acquired and hospital-acquired pneumonia, and skin and soft tissue infections, especially in immunocompromised patients or those with polymicrobial infections. Its broad coverage and ability to overcome bacterial resistance make it a critical choice for severe and complex infections where empirical therapy is often initiated.

Uses

• Treatment of complicated intra-abdominal infections.
• Management of hospital-acquired pneumonia.
• Treatment of complicated skin and soft tissue infections.
• Empirical therapy for febrile neutropenia.

Directions For Use

Administer intravenously by infusion over 30 minutes, as directed by a healthcare professional.

Benefits

• Broad spectrum of antibacterial coverage.
• Effective against beta-lactamase producing bacteria.
• Useful for severe and mixed bacterial infections.
• Penetrates well into various body tissues.
• Crucial for treating resistant bacterial strains.
• Can be used in immunocompromised patients.

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Rash
• Headache
• Insomnia
• Constipation
• Injection site reactions
• Increased liver enzymes
• Hypokalemia
• Anemia
• Allergic reactions (anaphylaxis)

Safety Measures

• Alcohol - No specific interaction with alcohol, but it's generally advisable to avoid alcohol during severe infections.
• Pregnancy - Use only if clearly needed; potential risks should be discussed with a healthcare provider.
• Breastfeeding - Small amounts may pass into breast milk; use with caution and monitor the infant for adverse effects.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests.
• Kidney - Dosage adjustment is necessary in patients with renal impairment due to renal excretion.
• Lung - Generally safe for lung conditions, often used to treat severe respiratory tract infections including pneumonia.

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