Cyclostim 50mg Capsule

About

Cyclosporine is a powerful immunosuppressant medication primarily utilized to prevent organ rejection in patients who have undergone solid organ transplantation, such as kidney, liver, or heart transplants. It is also effectively employed in the management of various severe autoimmune diseases where the immune system mistakenly attacks the body's own tissues. The drug functions by selectively inhibiting the activation and proliferation of T-lymphocytes, a critical type of white blood cell responsible for initiating and mediating immune responses. By suppressing these T-cells, cyclosporine helps the body accept the transplanted organ and significantly reduces the severity of autoimmune conditions. Its mechanism involves binding to cyclophilin, forming a complex that subsequently inhibits calcineurin, an enzyme essential for T-cell activation and the production of inflammatory cytokines. This targeted immunomodulation is key to its therapeutic action.

Uses

• Prevention of organ transplant rejection (kidney, liver, heart)
• Treatment of severe rheumatoid arthritis
• Management of severe psoriasis
• Treatment of severe atopic dermatitis

Directions For Use

Take orally as prescribed by your doctor, usually once or twice daily. Do not crush or chew capsules.

Benefits

• Prevents organ transplant rejection
• Manages severe autoimmune diseases
• Reduces inflammation in rheumatoid arthritis
• Clears skin lesions in psoriasis
• Suppresses overactive immune responses
• Improves quality of life for transplant recipients

Side Effects

• Kidney dysfunction (nephrotoxicity)
• High blood pressure (hypertension)
• Tremor
• Headache
• Gum hyperplasia
• Hirsutism (excessive hair growth)
• Nausea/vomiting
• Diarrhea
• Increased risk of infections
• Liver dysfunction
• Electrolyte disturbances (e.g., hyperkalemia)
• Fatigue

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can increase the risk of liver toxicity and other side effects.
• Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus. Discuss with your doctor.
• Breastfeeding - Cyclosporine passes into breast milk and can cause serious adverse effects in the infant. Breastfeeding is generally not recommended.
• Liver - Use with extreme caution in patients with liver impairment, as it can worsen liver function and requires dose adjustment.
• Kidney - Cyclosporine is nephrotoxic; close monitoring of kidney function is essential, and dose adjustments may be required.
• Lung - While not a primary concern, patients should be monitored for pulmonary infections due to immunosuppression.

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