Sandimmun Neoral 50mg Capsule

About

Cyclosporine, the active ingredient in Sandimmun Neoral, is a potent immunosuppressant medication primarily used to prevent organ rejection in transplant recipients (kidney, liver, heart, lung, pancreas). It works by inhibiting calcineurin, a phosphatase involved in activating T-lymphocytes. This action reduces the proliferation and function of T-cells, which are crucial mediators of the immune response responsible for rejecting foreign tissues. By suppressing the immune system, cyclosporine helps the body accept the transplanted organ, significantly improving graft survival rates.

It is also utilized in the treatment of severe autoimmune diseases where immune system overactivity causes tissue damage, such as severe rheumatoid arthritis, psoriasis, and nephrotic syndrome, when other treatments have failed. Careful monitoring of blood levels is essential due to its narrow therapeutic index and potential for nephrotoxicity and other side effects.

Uses

• Prevention of organ rejection in transplant patients.
• Treatment of severe rheumatoid arthritis.
• Management of severe psoriasis.
• Treatment of nephrotic syndrome.

Directions For Use

Take exactly as prescribed by your doctor, usually once or twice daily. Do not alter the dose or stop medication without medical advice.

Benefits

• Prevents rejection of transplanted organs.
• Manages severe autoimmune conditions.
• Reduces inflammation and immune response.
• Improves quality of life for transplant recipients.
• Effective in cases resistant to other therapies.
• Available in various formulations for flexible dosing.

Side Effects

• Kidney dysfunction (nephrotoxicity)
• High blood pressure (hypertension)
• Tremors
• Headache
• Excessive hair growth (hirsutism)
• Gum hyperplasia
• Nausea/vomiting
• Diarrhea
• Increased risk of infections
• Liver dysfunction
• Electrolyte disturbances (e.g., hyperkalemia)
• Increased risk of certain cancers (e.g., skin cancer, lymphoma)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of liver toxicity and other side effects.
• Pregnancy - Use only if clearly needed and the potential benefits outweigh the risks, as it can cross the placenta and may cause fetal harm. Discuss with your doctor.
• Breastfeeding - Not recommended during breastfeeding as cyclosporine is excreted in breast milk and can cause serious adverse effects in the infant.
• Liver - Use with extreme caution and reduced dosage in patients with liver impairment, as it is extensively metabolized by the liver. Close monitoring is essential.
• Kidney - Cyclosporine is nephrotoxic; use with caution and close monitoring of renal function, especially in patients with pre-existing kidney conditions.
• Lung - Generally safe for use in patients with lung conditions, but monitor for increased susceptibility to respiratory infections due to immunosuppression.

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