Dasanat 50mg Tablet

About

Dasanat 50mg Tablet is an advanced antineoplastic agent classified as a tyrosine kinase inhibitor (TKI), specifically designed to target and inhibit the activity of multiple key tyrosine kinases. Its primary mechanism involves blocking the BCR-ABL fusion protein, a critical oncogenic driver in chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). By interfering with these aberrant signaling pathways, Dasatinib, the active pharmaceutical ingredient, effectively halts the uncontrolled proliferation of cancerous cells and promotes their programmed cell death (apoptosis). This targeted approach makes it a highly effective therapeutic option for patients, particularly those who have developed resistance or intolerance to previous treatments, or as a first-line therapy in specific indications.

This medication is administered orally, offering a convenient and patient-friendly method for managing these complex hematological malignancies. Throughout the treatment course, vigilant monitoring of hematological parameters, liver and kidney function, and other clinical indicators is essential. This ensures the timely assessment of treatment efficacy, proactive management of potential adverse effects, and ultimately, the optimization of patient outcomes and quality of life.

Uses

• Treatment of newly diagnosed chronic phase Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML).
• Treatment of chronic, accelerated, or myeloid/lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy.
• Treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) with resistance or intolerance to prior therapy.
• Management of advanced Ph+ ALL in adult patients.

Directions For Use

Take this medicine orally as directed by your physician, usually once daily, with or without food. Do not crush, cut, or chew the tablet.

Benefits

• Targets specific cancer-driving enzymes.
• Effective in various phases of CML.
• Option for patients resistant to other treatments.
• Oral administration for convenience.
• Can induce durable hematologic and cytogenetic responses.
• Improves progression-free and overall survival in eligible patients.

Side Effects

• Fluid retention (e.g., pleural effusion, peripheral edema)
• Myelosuppression (anemia, neutropenia, thrombocytopenia)
• Diarrhea
• Nausea
• Fatigue
• Headache
• Rash
• Musculoskeletal pain
• Hemorrhage
• QT prolongation
• Pulmonary arterial hypertension (PAH)
• Abdominal pain

Safety Measures

• Alcohol - It is generally advisable to limit or avoid alcohol consumption while taking this medication, as it may exacerbate liver-related side effects or increase the risk of gastrointestinal irritation.
• Pregnancy - This medication is not recommended during pregnancy due to potential harm to the fetus. Effective contraception should be used by women of childbearing potential during treatment and for a period after.
• Breastfeeding - Breastfeeding is not recommended during treatment with this medication and for a period after the last dose, as the drug may pass into breast milk and cause serious adverse effects in the infant.
• Liver - Use with caution in patients with pre-existing liver conditions. Dose adjustments may be necessary, and liver function should be monitored regularly during treatment.
• Kidney - Caution is advised in patients with renal impairment. Dose adjustments may be required based on the severity of kidney dysfunction, and renal function should be monitored.
• Lung - Patients should be monitored for signs of pulmonary complications, including pleural effusion and pulmonary arterial hypertension (PAH), which are known side effects.

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