Delcade 2mg Injection

About

Delcade 2mg Injection is a potent antineoplastic agent belonging to the class of proteasome inhibitors. It works by reversibly inhibiting the 26S proteasome, a multi-catalytic proteinase complex responsible for degrading ubiquitinated proteins. This inhibition disrupts various cellular processes, including cell cycle progression, apoptosis, and angiogenesis, leading to the accumulation of misfolded proteins and ultimately inducing programmed cell death in cancer cells.

It is particularly effective against hematological malignancies where proteasome activity is often dysregulated. Its mechanism of action targets specific pathways crucial for cancer cell survival and proliferation, making it a valuable therapeutic option in certain advanced cancers.

Uses

• Treatment of multiple myeloma.
• Management of mantle cell lymphoma.
• Used in combination chemotherapy regimens.
• For patients who have received prior therapy.

Directions For Use

Administer intravenously or subcutaneously by a healthcare professional. Dosage and schedule are determined by the treating physician based on the specific condition and patient response.

Benefits

• Targets specific cancer cell pathways.
• Effective in relapsed/refractory multiple myeloma.
• Improves progression-free survival.
• Can be used in combination therapies.
• Offers a targeted approach to cancer treatment.
• May induce remission in certain patients.

Side Effects

• Peripheral neuropathy
• Thrombocytopenia
• Neutropenia
• Fatigue
• Nausea
• Diarrhea
• Constipation
• Vomiting
• Pyrexia
• Anemia
• Rash
• Hypotension

Safety Measures

• Alcohol - Avoid alcohol as it may exacerbate certain side effects like neuropathy or liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm; effective contraception is required.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary.
• Kidney - Generally safe in renal impairment, but close monitoring is advised; no dose adjustment typically needed for mild to moderate.
• Lung - Monitor for new or worsening pulmonary symptoms, as interstitial lung disease can occur.

Disclaimer

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