Docet 120mg Injection

About

Docetaxel is a potent antineoplastic agent belonging to the taxane class, which functions by disrupting the dynamic equilibrium of the microtubule network within cells. It achieves this by promoting the assembly of tubulin into stable microtubules and simultaneously inhibiting their depolymerization. This stabilization prevents the normal functioning of microtubules, which are critical for various cellular processes, particularly cell division. The resulting accumulation of non-functional microtubules leads to cell cycle arrest in the G2/M phase and ultimately induces programmed cell death (apoptosis) in rapidly proliferating cancer cells. Its efficacy makes it a cornerstone in the treatment of several advanced solid tumors.

Uses

• Treatment of metastatic breast cancer.
• Management of non-small cell lung cancer.
• Treatment of prostate cancer.
• Management of head and neck cancer.

Directions For Use

Administer intravenously by a qualified healthcare professional, typically as a 1-hour infusion, with premedication to reduce hypersensitivity reactions.

Benefits

• Highly effective against various solid tumors.
• Induces cell cycle arrest and apoptosis in cancer cells.
• Can be used in combination with other chemotherapies.
• Demonstrates significant clinical response rates.
• Improves overall survival in certain malignancies.
• Well-established safety and efficacy profile.

Side Effects

• Myelosuppression (neutropenia, anemia, thrombocytopenia)
• Hypersensitivity reactions
• Fluid retention (edema)
• Peripheral neuropathy
• Alopecia (hair loss)
• Nausea and vomiting
• Diarrhea
• Stomatitis/mucositis
• Fatigue/asthenia
• Nail changes
• Skin reactions
• Muscle and joint pain

Safety Measures

• Alcohol - Alcohol should be strictly avoided during treatment as it can exacerbate gastrointestinal side effects and may interact with the drug's metabolism.
• Pregnancy - This medication is contraindicated in pregnancy due to its genotoxic and teratogenic potential; effective contraception is mandatory during treatment.
• Breastfeeding - Breastfeeding is contraindicated during treatment and for a period after the last dose due to the potential for serious adverse effects on the infant.
• Liver - Dose adjustments are crucial for patients with hepatic impairment, and liver function should be closely monitored due to the drug's metabolism and excretion.
• Kidney - No specific dose adjustment is typically required for renal impairment, but caution is advised, and renal function should be monitored.
• Lung - Patients should be monitored for signs of pulmonary toxicity, such as interstitial pneumonia or acute respiratory distress syndrome, though these are rare.

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