Droxiget 500mg Capsule

About

Droxidopa is an orally administered synthetic amino acid precursor of norepinephrine, indicated for the treatment of symptomatic neurogenic orthostatic hypotension (nOH). In patients with nOH, there is a deficiency in norepinephrine production, leading to a significant drop in blood pressure upon standing, causing symptoms such as dizziness, lightheadedness, and syncope. Droxidopa is converted to norepinephrine by the enzyme dopa-decarboxylase, primarily in the peripheral nervous system.

This increases the levels of norepinephrine, which then acts on alpha-1 adrenergic receptors in the vasculature, leading to vasoconstriction and an elevation in blood pressure when standing. This mechanism helps to alleviate the debilitating symptoms associated with nOH, improving the patient's ability to perform daily activities and reducing the risk of falls.

Uses

• Treatment of symptomatic neurogenic orthostatic hypotension (nOH).
• Alleviates dizziness and lightheadedness upon standing.
• Reduces the risk of syncope (fainting) associated with nOH.
• Improves daily activity tolerance in nOH patients.

Directions For Use

Take this capsule orally, usually three times daily, as prescribed by your doctor. Swallow the capsule whole with water.

Benefits

• Effectively raises blood pressure in nOH patients.
• Reduces symptoms like dizziness and lightheadedness.
• Improves patient's ability to stand and perform activities.
• Oral administration for patient convenience.
• Specifically targets norepinephrine deficiency in nOH.
• Can improve quality of life for individuals with nOH.

Side Effects

• Headache
• Nausea
• Hypertension (supine hypertension)
• Fatigue
• Dizziness
• Urinary tract infection
• Abdominal pain
• Vomiting
• Diarrhea
• Peripheral edema
• Rash
• Bradycardia

Safety Measures

• Alcohol - Alcohol may exacerbate orthostatic hypotension or interact with the medication; use with caution.
• Pregnancy - Droxidopa should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a physician.
• Breastfeeding - It is unknown if droxidopa is excreted in human milk. Exercise caution when administering to a breastfeeding woman.
• Liver - Use with caution in patients with hepatic impairment. Monitor liver function tests and adjust dose if necessary.
• Kidney - Use with caution in patients with renal impairment. Dose adjustments may be required based on kidney function.
• Lung - No specific lung-related precautions are typically noted, but general cardiovascular monitoring is important.

Disclaimer

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