Durea 500mg Capsule

About

Durea 500mg Capsule is an antineoplastic agent primarily used in the management of various myeloproliferative disorders and certain other conditions. Its mechanism of action involves inhibiting ribonucleotide reductase, an enzyme crucial for the synthesis of deoxyribonucleotides, which are essential building blocks for DNA. By interfering with DNA synthesis and repair, Durea selectively targets rapidly dividing cells, including cancer cells and those involved in abnormal blood cell production.

This oral medication helps to reduce elevated blood cell counts, alleviate symptoms, and prevent complications associated with conditions like chronic myeloid leukemia, sickle cell anemia, and essential thrombocythemia. Its cytoreductive effects are dose-dependent and require careful monitoring of hematological parameters to balance efficacy with potential myelosuppression. Durea plays a vital role in long-term disease management for many patients.

Uses

• Treatment of chronic myeloid leukemia (CML)
• Management of sickle cell anemia
• Therapy for essential thrombocythemia
• Control of polycythemia vera

Directions For Use

Take this capsule orally, usually once daily, with a glass of water, as directed by your physician.

Benefits

• Reduces white blood cell counts in CML
• Decreases painful crises in sickle cell anemia
• Controls platelet and red blood cell counts
• Convenient oral administration
• Improves quality of life for chronic conditions
• Reduces splenomegaly in myeloproliferative disorders

Side Effects

• Myelosuppression (leukopenia, thrombocytopenia, anemia)
• Nausea and vomiting
• Diarrhea
• Mouth sores (stomatitis)
• Skin hyperpigmentation
• Nail changes
• Fever
• Headache
• Dizziness
• Skin rash
• Leg ulcers
• Anorexia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to potential for increased liver toxicity and general debilitation.
• Pregnancy - Contraindicated; Durea is teratogenic and fetotoxic, causing severe harm to the developing fetus.
• Breastfeeding - Contraindicated; the drug passes into breast milk and can cause serious adverse effects in the nursing infant.
• Liver - Use with caution in patients with liver impairment; monitor liver function regularly during treatment.
• Kidney - Dose adjustment is required in patients with kidney impairment due to renal excretion; increased risk of toxicity.
• Lung - Can cause interstitial lung disease or pulmonary fibrosis; monitor for new or worsening respiratory symptoms.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.