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About

Fosfomycin trometamol is a broad-spectrum bactericidal antibiotic indicated for the treatment of uncomplicated urinary tract infections (UTIs) in women caused by susceptible strains of Escherichia coli and Enterococcus faecalis. It works by inhibiting bacterial cell wall synthesis at an early stage, specifically by inactivating the enzyme UDP-N-acetylglucosamine enolpyruvyl transferase. This unique mechanism of action minimizes cross-resistance with other antibiotic classes.

Its single-dose regimen makes it a convenient and effective option for acute cystitis, providing high concentrations in the urine for an extended period. Fosfomycin is well-absorbed and rapidly excreted in the urine, ensuring targeted action at the site of infection, making it a valuable choice for managing acute, uncomplicated UTIs.

Uses

• Treatment of uncomplicated urinary tract infections.
• Acute cystitis in women.
• Infections caused by E. coli.
• Infections caused by E. faecalis.

Directions For Use

Dissolve the entire contents of the sachet in half a glass of water and drink immediately. Take as a single dose, preferably at bedtime after emptying the bladder.

Benefits

• Effective against common UTI pathogens.
• Convenient single-dose treatment.
• Unique mechanism of action.
• Low potential for cross-resistance.
• Achieves high urinary concentrations.
• Generally well-tolerated.

Side Effects

• Diarrhea
• Nausea
• Headache
• Dizziness
• Abdominal pain
• Dyspepsia
• Vaginitis
• Rash
• Fatigue
• Back pain
• Rhinitis
• Pharyngitis

Safety Measures

• Alcohol - Alcohol does not directly interact with fosfomycin, but it's generally advisable to avoid it during infection to support recovery.
• Pregnancy - Use with caution during pregnancy; consult a doctor. It is generally considered safe for uncomplicated UTIs when benefits outweigh risks.
• Breastfeeding - Fosfomycin is excreted in breast milk. Use with caution; consider potential risks to the infant versus benefits to the mother.
• Liver - No specific dosage adjustment is typically required for patients with liver impairment.
• Kidney - Dosage adjustment may be necessary in severe renal impairment. Use with caution and monitor kidney function.
• Lung - No specific precautions for lung conditions are typically noted for fosfomycin.

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