Emend 125mg/80mg Capsule

About

Emend 125mg/80mg Capsule contains aprepitant, a selective neurokinin-1 (NK1) receptor antagonist, specifically designed for the prevention of chemotherapy-induced nausea and vomiting (CINV). Aprepitant works by blocking the binding of substance P, a key neuropeptide, to the NK1 receptors in the brain's emetic center. This action effectively inhibits both the acute and, more importantly, the delayed phases of CINV, which are often difficult to control with other antiemetics alone. The delayed phase of CINV can persist for several days after chemotherapy and significantly impact a patient's quality of life.

Emend is typically administered as part of a multi-day regimen, often in combination with a 5-HT3 receptor antagonist and a corticosteroid, to provide comprehensive antiemetic protection for patients receiving highly or moderately emetogenic chemotherapy. Its oral formulation offers convenience for patients, allowing for continued antiemetic coverage at home. By targeting a distinct pathway in the emetic reflex, Emend plays a crucial role in improving patient comfort, reducing the burden of CINV, and supporting adherence to critical cancer treatment protocols.

Uses

• Prevention of acute and delayed CINV associated with highly emetogenic chemotherapy
• Prevention of acute and delayed CINV associated with moderately emetogenic chemotherapy
• Used as part of a combination antiemetic regimen
• Prevention of post-operative nausea and vomiting (PONV)

Directions For Use

Take orally as directed by your physician, typically 125mg on Day 1, then 80mg on Days 2 and 3.

Benefits

• Highly effective for preventing delayed CINV
• Synergistic with 5-HT3 antagonists and corticosteroids
• Provides sustained antiemetic protection over several days
• Significantly improves overall CINV control
• Reduces the need for rescue antiemetic medications
• Oral formulation offers convenience for patients

Side Effects

• Fatigue
• Hiccups
• Headache
• Constipation
• Dizziness
• Dyspepsia (indigestion)
• Anorexia (loss of appetite)
• Weakness
• Skin rash
• Abdominal pain
• Neutropenia (low white blood cell count)
• Dehydration

Safety Measures

• Alcohol - No specific interaction with alcohol is known. However, it is generally advisable to avoid alcohol if feeling unwell or experiencing nausea.
• Pregnancy - Consult your doctor before use during pregnancy. It should only be used if the potential benefits clearly justify the potential risks to the fetus.
• Breastfeeding - Consult your doctor. It is unknown if the medication is excreted in breast milk, and potential effects on the infant are not fully established.
• Liver - Use with caution in patients with severe liver impairment. Dose adjustment may be necessary due to altered drug metabolism.
• Kidney - Generally considered safe for use in patients with kidney conditions. No specific dose adjustment is usually required for renal impairment.
• Lung - Generally safe for use in patients with lung conditions. No specific lung concerns or adverse effects are typically associated with this medication.

Disclaimer

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