Etosid 100mg Injection

About

Etosid 100mg Injection contains Etoposide, an antineoplastic agent classified as a topoisomerase II inhibitor. It exerts its cytotoxic effects by forming a ternary complex with topoisomerase II and DNA, which prevents the re-ligation of DNA strands after cleavage. This leads to DNA damage, accumulation of cells in the G2/M phase of the cell cycle, and ultimately triggers apoptosis (programmed cell death) in rapidly dividing cancer cells. Etoposide is cell cycle-specific, primarily affecting cells in the late S and G2 phases.

This medication is widely used in combination chemotherapy regimens for various malignancies. Its primary indications include the treatment of refractory testicular tumors, small cell lung cancer, non-Hodgkin's lymphoma, Hodgkin's disease, and acute myeloid leukemia. It is often administered intravenously as part of a multi-drug protocol to maximize its therapeutic efficacy and overcome potential drug resistance. Due to its potent cytotoxic nature, administration requires careful monitoring by experienced healthcare professionals.

Uses

• Treatment of refractory testicular tumors.
• Management of small cell lung cancer.
• Therapy for non-Hodgkin's lymphoma.
• Treatment of acute myeloid leukemia.

Directions For Use

Etosid 100mg Injection is administered intravenously by a qualified healthcare professional. The dosage and schedule will be determined by your doctor based on your condition and other treatments.

Benefits

• Effective against various solid tumors.
• Induces apoptosis in cancer cells.
• Used in combination chemotherapy regimens.
• Helps manage refractory testicular cancer.
• Improves outcomes in small cell lung cancer.
• Contributes to remission in certain leukemias.

Side Effects

• Nausea and vomiting
• Hair loss (alopecia)
• Myelosuppression (low blood counts)
• Fatigue
• Diarrhea
• Anorexia
• Oral mucositis
• Hypotension (during infusion)
• Peripheral neuropathy
• Allergic reactions
• Liver enzyme elevation
• Secondary malignancies (rare)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate side effects or interact with the medication.
• Pregnancy - Etosid is contraindicated in pregnancy due to significant risk of fetal harm. Effective contraception is essential for both male and female patients.
• Breastfeeding - Breastfeeding is contraindicated during treatment and for a period after, as Etoposide is excreted in breast milk and can harm the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary. Liver function should be closely monitored.
• Kidney - Dose reduction is often required in patients with moderate to severe renal impairment. Kidney function should be regularly assessed.
• Lung - Rarely, interstitial pneumonitis has been reported. Monitor for new or worsening respiratory symptoms.

Disclaimer

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