Exetraz 25mg Tablet

About

Exetraz 25mg Tablet contains Exemestane, an irreversible steroidal aromatase inactivator used in the adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women. It is typically prescribed after patients have completed 2-3 years of tamoxifen therapy, or for advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy. Exemestane works by permanently binding to and inactivating the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues.

By irreversibly blocking aromatase, Exemestane significantly reduces estrogen levels in the body, thereby depriving estrogen-sensitive breast cancer cells of the growth stimulus. This mechanism of action makes it a potent endocrine therapy, helping to prevent recurrence and slow the progression of hormone-dependent breast cancers in postmenopausal women.

Uses

• Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women.
• Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
• Extended adjuvant treatment of early breast cancer in postmenopausal women after 2-3 years of tamoxifen.
• Prevention of breast cancer in high-risk postmenopausal women (off-label).

Directions For Use

Take one tablet orally once daily after a meal, at approximately the same time each day, as directed by your doctor.

Benefits

• Irreversibly inactivates the aromatase enzyme, leading to sustained estrogen reduction.
• Effective in hormone receptor-positive breast cancer, including those resistant to tamoxifen.
• Improves disease-free survival and reduces recurrence risk.
• Oral administration offers convenience for long-term therapy.
• Well-established efficacy in the adjuvant and advanced settings.
• Steroidal structure may offer a different side effect profile compared to non-steroidal aromatase inhibitors.

Side Effects

• Hot flashes
• Nausea
• Fatigue
• Joint pain (arthralgia)
• Headache
• Insomnia
• Increased sweating
• Hair thinning (alopecia)
• Bone pain
• Dizziness
• Depression
• Vomiting

Safety Measures

• Alcohol - Moderate alcohol consumption is generally not contraindicated, but excessive intake may exacerbate some side effects like liver issues or dizziness.
• Pregnancy - Contraindicated in pregnant women as it can cause fetal harm. Effective contraception must be used by premenopausal women if there is a possibility of pregnancy.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant and suppression of milk production.
• Liver - Use with caution in patients with moderate to severe liver impairment; dose adjustment may be necessary. Monitor liver function regularly.
• Kidney - No dose adjustment is typically required for mild to moderate renal impairment. Use with caution in severe impairment, though data is limited.
• Lung - Generally no specific lung-related precautions, but monitor for any new or worsening respiratory symptoms.

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