Fosfa 1gm Injection

About

Fosfa 1gm Injection contains Ifosfamide, an alkylating agent belonging to the nitrogen mustard group of chemotherapeutic drugs. It is widely used in the treatment of various neoplastic diseases. Ifosfamide exerts its cytotoxic effects by forming covalent bonds with DNA, leading to cross-linking of DNA strands. This process inhibits DNA replication and transcription, ultimately disrupting cell division and inducing apoptosis in rapidly proliferating cancer cells.

This medication is a prodrug that requires metabolic activation in the liver to its active forms. Due to its potential for urotoxicity, specifically hemorrhagic cystitis, it is almost always co-administered with a uroprotectant like Mesna to safeguard the bladder. Fosfa 1gm Injection is a critical component in multi-drug chemotherapy regimens for aggressive cancers, aiming to achieve remission and improve patient survival.

Uses

• Testicular cancer
• Soft tissue sarcoma
• Lymphoma
• Osteosarcoma

Directions For Use

Administered intravenously under strict medical supervision. Always co-administer with a uroprotectant like Mesna.

Benefits

• Effective against a range of solid tumors
• Part of established multi-drug regimens
• Can induce remission in various cancers
• Slows disease progression
• Improves survival in specific cancers
• Versatile in oncology treatment

Side Effects

• Myelosuppression
• Nausea
• Vomiting
• Hemorrhagic cystitis
• Neurotoxicity
• Alopecia
• Fatigue
• Nephrotoxicity
• Stomatitis
• Diarrhea
• Infection
• Fever

Safety Measures

• Alcohol - Avoid; can exacerbate side effects and increase liver strain.
• Pregnancy - Contraindicated; highly teratogenic and can cause severe fetal harm.
• Breastfeeding - Contraindicated; potential for serious adverse reactions in breastfed infants.
• Liver - Use with extreme caution; dose adjustment may be necessary, monitor liver function closely.
• Kidney - Use with extreme caution; dose adjustment may be necessary, monitor renal function closely.
• Lung - Monitor for pulmonary toxicity, including interstitial pneumonitis.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.