FRITOLEV 250 MG 10 TAB

About

Levetiracetam is an antiepileptic drug (AED) primarily used in the treatment of various seizure disorders. Its precise mechanism of action is not fully understood but is believed to involve binding to the synaptic vesicle protein 2A (SV2A) in the brain, which modulates neurotransmitter release and helps to normalize neuronal excitability. Unlike many other AEDs, levetiracetam does not appear to act via GABAergic or glutamatergic pathways directly, nor does it significantly interact with sodium or calcium channels.

It is effective as monotherapy or adjunctive therapy for partial-onset seizures with or without secondary generalization, myoclonic seizures in patients with juvenile myoclonic epilepsy, and primary generalized tonic-clonic seizures in patients with idiopathic generalized epilepsy. Levetiracetam is generally well-tolerated, with a favorable pharmacokinetic profile and minimal drug-drug interactions, making it a valuable option in epilepsy management.

Uses

• Treatment of partial-onset seizures.
• Management of myoclonic seizures.
• Therapy for primary generalized tonic-clonic seizures.
• Adjunctive treatment for various epilepsy syndromes.

Directions For Use

Take this medication orally, usually twice daily, with or without food, as prescribed by your doctor. Swallow the tablet whole with water.

Benefits

• Effective in controlling various seizure types.
• Generally well-tolerated with fewer side effects than some AEDs.
• Minimal drug-drug interactions.
• Can be used as monotherapy or adjunctive therapy.
• Rapid onset of action.
• Available in multiple formulations for flexibility.

Side Effects

• Somnolence (drowsiness)
• Asthenia (weakness)
• Dizziness
• Headache
• Irritability
• Nasal congestion
• Anorexia (loss of appetite)
• Infection (e.g., nasopharyngitis)
• Behavioral changes (e.g., aggression, agitation)
• Mood swings
• Nausea
• Diarrhea

Safety Measures

• Alcohol - While there are no specific contraindications, alcohol can exacerbate CNS depression and dizziness. It is generally advisable to limit or avoid alcohol.
• Pregnancy - Levetiracetam should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Discuss risks and benefits with your doctor.
• Breastfeeding - Levetiracetam is excreted in human milk. Breastfeeding is generally not recommended unless the potential benefits outweigh the risks to the infant.
• Liver - No dose adjustment is typically required for patients with mild to moderate hepatic impairment. Use with caution in severe liver disease.
• Kidney - Dose adjustment is necessary for patients with impaired renal function, as levetiracetam is primarily excreted by the kidneys.
• Lung - Generally safe for use in patients with lung conditions. No specific precautions are usually required, but monitor for any unusual respiratory symptoms.

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