Geftin 250mg Tablet

About

Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It works by blocking the activity of the EGFR enzyme, which is often overactive in certain types of cancer cells, particularly non-small cell lung cancer (NSCLC). By inhibiting EGFR, gefitinib helps to prevent the growth and spread of cancer cells. It is typically used in patients with advanced or metastatic NSCLC whose tumors have specific EGFR mutations, as identified by a diagnostic test. This targeted therapy offers a more specific approach compared to traditional chemotherapy, aiming to reduce tumor size and improve progression-free survival in responsive patients.

The drug is administered orally and is absorbed into the bloodstream, where it then targets the cancer cells. Its efficacy is closely linked to the presence of activating EGFR mutations, making patient selection crucial for optimal therapeutic outcomes. Regular monitoring for treatment response and potential side effects is essential throughout the course of therapy.

Uses

• Non-small cell lung cancer (NSCLC) with EGFR mutations.
• Advanced or metastatic NSCLC.
• First-line treatment for specific NSCLC patients.
• Second-line treatment after chemotherapy failure in some cases.

Directions For Use

Take this medicine orally as directed by your doctor, usually once daily with or without food. Do not crush or chew the tablet.

Benefits

• Targeted therapy for specific lung cancers.
• May improve progression-free survival.
• Oral administration for convenience.
• Potential for fewer systemic side effects than chemotherapy.
• Can reduce tumor size in responsive patients.
• Improves quality of life in some patients.

Side Effects

• Diarrhea
• Skin rash
• Nausea
• Vomiting
• Anorexia
• Dry skin
• Pruritus
• Stomatitis
• Conjunctivitis
• Elevated liver enzymes
• Interstitial lung disease (rare but serious)
• Nail disorders

Safety Measures

• Alcohol - It is generally advisable to limit or avoid alcohol consumption as it may exacerbate some side effects or impact liver function, which is relevant for drug metabolism.
• Pregnancy - This medication is not recommended during pregnancy as it may cause fetal harm. Effective contraception should be used by women of childbearing potential.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after the last dose, as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with pre-existing liver impairment. Liver function should be monitored regularly, and dose adjustments may be necessary.
• Kidney - Generally, no dose adjustment is required for mild to moderate renal impairment, but caution is advised in severe cases.
• Lung - Patients should be monitored for new or worsening pulmonary symptoms, as interstitial lung disease (ILD) is a rare but serious side effect.

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