Gempower 1gm Injection

About

Gempower 1gm Injection contains Gemcitabine, a pyrimidine antimetabolite that acts as a potent cytotoxic agent by interfering with DNA synthesis and repair in rapidly proliferating cancer cells. Once inside the cell, it is phosphorylated to its active diphosphate and triphosphate forms. These metabolites inhibit ribonucleotide reductase, reducing the deoxynucleotide pool necessary for DNA synthesis, and are incorporated into DNA, leading to chain termination and apoptosis. This dual mechanism makes gemcitabine effective against a broad spectrum of solid tumors, including advanced pancreatic, non-small cell lung, breast, and ovarian cancers, often improving patient outcomes. It is a cornerstone in many chemotherapy regimens, aiming to control disease progression and improve survival.

Uses

• Pancreatic cancer.
• Non-small cell lung cancer.
• Breast cancer.
• Ovarian cancer.

Directions For Use

Administer intravenously under the supervision of a qualified healthcare professional.

Benefits

• Effective against various solid tumors.
• Can improve survival in advanced cancers.
• Often used in combination regimens.
• May reduce tumor size and symptoms.
• Relatively well-tolerated compared to some other chemotherapies.
• Established efficacy in multiple cancer types.

Side Effects

• Myelosuppression (low blood counts)
• Nausea
• Vomiting
• Fatigue
• Flu-like symptoms
• Rash
• Hair loss (alopecia)
• Diarrhea
• Constipation
• Liver enzyme elevation
• Kidney dysfunction
• Peripheral edema

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased liver toxicity and gastrointestinal irritation.
• Pregnancy - Contraindicated; can cause severe fetal harm. Effective contraception is required.
• Breastfeeding - Not recommended; discontinue breastfeeding during treatment due to potential harm to the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function closely. Dose adjustment may be needed.
• Kidney - Use with caution in patients with renal impairment; monitor renal function closely. Dose adjustment may be needed.
• Lung - Can cause severe pulmonary toxicity, including interstitial pneumonitis and ARDS; monitor for respiratory symptoms.

Disclaimer

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