GLISEN MF 2 15S

About

GLISEN MF 2 is a combination medication containing Glimepiride 2mg and Metformin, specifically designed for the comprehensive treatment of type 2 diabetes mellitus. Glimepiride, a third-generation sulfonylurea, acts by stimulating insulin secretion from the pancreatic beta cells, thereby directly lowering blood glucose levels. It achieves this by binding to specific receptors on the beta-cell membrane, leading to depolarization and subsequent insulin release. Metformin, a biguanide, complements this action by primarily reducing hepatic glucose production, decreasing intestinal glucose absorption, and improving insulin sensitivity in peripheral tissues.

This synergistic combination addresses both insulin deficiency and insulin resistance, providing robust glycemic control. It is particularly beneficial for adults with type 2 diabetes whose blood sugar levels are not adequately managed by diet and exercise alone, or by monotherapy with either agent, helping to achieve target HbA1c levels.

Uses

• Management of type 2 diabetes mellitus.
• Improvement of glycemic control.
• Used as an adjunct to diet and exercise.
• When monotherapy is inadequate.

Directions For Use

Take this medication orally, usually once or twice daily with meals, as prescribed by your doctor.

Benefits

• Comprehensive blood sugar control.
• Dual mechanism of action.
• Reduced HbA1c levels.
• Improved insulin sensitivity.
• Reduced hepatic glucose production.
• Effective for moderate to severe hyperglycemia.

Side Effects

• Hypoglycemia (common)
• Nausea
• Diarrhea
• Vomiting
• Abdominal discomfort
• Headache
• Dizziness
• Metallic taste
• Weight gain (due to glimepiride)
• Skin rash
• Lactic acidosis (rare, serious)
• Vitamin B12 deficiency (with long-term metformin)

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it increases the risk of hypoglycemia and lactic acidosis.
• Pregnancy - Not recommended during pregnancy; insulin is generally preferred for glycemic control.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk; consult a doctor.
• Liver - Use with caution in patients with liver impairment; increased risk of hypoglycemia and lactic acidosis.
• Kidney - Contraindicated in severe renal impairment due to metformin accumulation risk; dose adjustment needed for moderate impairment.
• Lung - Severe respiratory conditions increasing hypoxia risk may increase lactic acidosis risk; use with caution.

Disclaimer

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