About

This medication combines Metformin, a biguanide, and Glimepiride, a sulfonylurea, to offer a comprehensive approach to managing type 2 diabetes mellitus. Metformin primarily works by decreasing glucose production in the liver and improving the body's sensitivity to insulin in muscle and fat tissues, leading to better glucose uptake. Glimepiride, on the other hand, stimulates the pancreatic beta cells to release more insulin, particularly after meals, thereby helping to lower postprandial blood glucose. Together, these agents effectively lower both fasting and postprandial blood glucose levels, making it a suitable option for adults whose blood sugar is not adequately controlled by diet, exercise, or monotherapy with either drug. This combination therapy aims to achieve better glycemic targets and reduce the risk of diabetes-related complications by addressing multiple aspects of glucose dysregulation.

Uses

Management of type 2 diabetes mellitus.
Improvement of blood glucose control.
When monotherapy is insufficient.
As an adjunct to diet and exercise.

Directions For Use

Take orally with meals to minimize gastrointestinal upset. Adhere strictly to the dosage prescribed by your healthcare provider.

Benefits

Dual mechanism for effective glucose lowering.
Reduces fasting and post-meal blood sugar.
Enhances insulin sensitivity.
Stimulates insulin secretion.
Convenient fixed-dose combination.
Helps achieve HbA1c targets.

Side Effects

Hypoglycemia
Nausea
Diarrhea
Abdominal pain
Metallic taste
Headache
Dizziness
Weight gain
Lactic acidosis (rare)
Vitamin B12 deficiency
Skin rash
Photosensitivity

Safety Measures

Alcohol - Excessive alcohol intake should be avoided due to increased risk of hypoglycemia and lactic acidosis, especially with metformin.
Pregnancy - Not generally recommended during pregnancy; insulin is typically preferred for managing gestational diabetes or pre-existing diabetes in pregnancy.
Breastfeeding - Avoid during breastfeeding as both active ingredients may pass into breast milk and could potentially harm the infant.
Liver - Contraindicated in severe hepatic impairment due to increased risk of lactic acidosis and prolonged drug effects.
Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to the risk of metformin accumulation and lactic acidosis.
Lung - Use with caution in conditions causing hypoxia (e.g., severe respiratory failure) as it may increase the risk of lactic acidosis.

Disclaimer

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