GLIMULIN 2MF 15S

About

GLIMULIN 2MF is a combination medication containing Glimipiride and Metformin, indicated for the management of Type 2 Diabetes Mellitus. Glimipiride, a sulfonylurea, primarily works by stimulating the pancreatic beta cells to release more insulin, thereby lowering blood glucose levels. Its action is dependent on the presence of functioning beta cells. Metformin, a biguanide, acts through several mechanisms: it decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by enhancing peripheral glucose uptake and utilization.

This fixed-dose combination provides a dual approach to glycemic control, addressing both insulin secretion and insulin resistance. It is suitable for patients who require effective glycemic management when lower doses or monotherapy are insufficient. GLIMULIN 2MF is used as an adjunct to diet and exercise when these measures alone are insufficient to control blood sugar, helping to achieve and maintain target blood glucose levels and prevent long-term complications of diabetes.

Uses

• Management of Type 2 Diabetes Mellitus.
• When diet and exercise alone are insufficient.
• When monotherapy with Glimipiride or Metformin is inadequate.
• To achieve stringent glycemic targets in adult patients.

Directions For Use

Take orally with meals, usually once or twice daily, as prescribed by your doctor. Swallow the tablet whole with water, do not crush or chew.

Benefits

• Potent reduction in blood glucose and HbA1c.
• Dual mechanism addressing insulin secretion and sensitivity.
• Effective for patients needing intensive glycemic control.
• Helps prevent long-term diabetes complications.
• Improved glucose utilization by peripheral tissues.
• Convenient fixed-dose combination.

Side Effects

• Hypoglycemia
• Nausea
• Diarrhea
• Abdominal discomfort
• Vomiting
• Headache
• Dizziness
• Weight gain
• Metallic taste
• Skin rash
• Lactic acidosis (rare, serious with Metformin)
• Anemia (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to increased risk of hypoglycemia (with Glimipiride) and lactic acidosis (with Metformin).
• Pregnancy - Contraindicated during pregnancy due to potential fetal harm and increased risk of neonatal hypoglycemia. Insulin is generally preferred.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and cause hypoglycemia in the infant.
• Liver - Contraindicated in severe hepatic impairment due to increased risk of lactic acidosis and prolonged drug effects.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dosage adjustment is crucial for moderate impairment.
• Lung - Use with caution in conditions causing hypoxia (e.g., severe lung disease) as it may increase the risk of lactic acidosis.

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