Herduo 250mg Tablet

About

Herduo 250mg Tablet is an oral targeted therapy, likely a dual tyrosine kinase inhibitor, designed to block the activity of both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). By inhibiting these critical signaling pathways, it prevents the growth and division of cancer cells that rely on these receptors for proliferation. This dual inhibition makes it particularly effective in treating certain HER2-positive cancers, especially those that may have developed resistance to other HER2-targeted therapies.

This medication is typically used in combination with other anti-cancer agents, offering a convenient oral administration route for patients. It plays a vital role in managing advanced or metastatic HER2-positive breast cancer, particularly in patients who have progressed after prior treatments. Close monitoring for potential side effects, including gastrointestinal issues and liver toxicity, is essential during the course of treatment.

Uses

• Treatment of HER2-positive advanced or metastatic breast cancer.
• Used in combination with capecitabine for advanced breast cancer.
• Management of hormone receptor-positive, HER2-positive breast cancer.
• For patients who have progressed on prior HER2-targeted therapies.

Directions For Use

Take orally, usually once daily, with or without food as directed by a physician. Do not crush or chew the tablet.

Benefits

• Convenient oral administration for patients.
• Dual targeting of EGFR and HER2 receptors.
• Effective in combination with other chemotherapy agents.
• Active in patients who may be resistant to other HER2 therapies.
• Potential for activity against brain metastases.
• Improves progression-free survival in advanced disease.

Side Effects

• Diarrhea.
• Rash (including hand-foot syndrome).
• Nausea and vomiting.
• Fatigue.
• Stomatitis (mouth sores).
• Hepatotoxicity (liver damage).
• Cardiac dysfunction (e.g., decreased LVEF).
• Interstitial lung disease (rare).
• Abdominal pain.
• Alopecia (hair loss).
• Dry skin.
• Dyspepsia.

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased liver toxicity and gastrointestinal side effects.
• Pregnancy - Contraindicated; can cause fetal harm. Women of childbearing potential must use effective contraception during and for a period after treatment.
• Breastfeeding - Not recommended; potential for excretion into breast milk and serious adverse reactions in the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are often required, and liver function must be closely monitored.
• Kidney - Use with caution in patients with severe renal impairment; no specific dose adjustments, but monitor for adverse effects.
• Lung - Monitor for signs of interstitial lung disease or pneumonitis; use with caution in patients with pre-existing pulmonary conditions.

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