INDERAL 40 10S

About

Propranolol is a non-selective beta-adrenergic receptor blocker, widely utilized in cardiovascular medicine. It exerts its therapeutic effects by competitively blocking beta-1 and beta-2 adrenergic receptors, thereby inhibiting the action of endogenous catecholamines like epinephrine and norepinephrine. This blockade leads to a reduction in heart rate, myocardial contractility, and cardiac output, which collectively contribute to its antihypertensive and anti-anginal properties. In conditions like angina pectoris, it decreases the heart's oxygen demand, effectively alleviating chest pain and improving exercise tolerance. For migraine prophylaxis, its mechanism involves stabilizing vascular tone and potentially modulating central nervous system activity. Furthermore, its anxiolytic effects are attributed to blocking the peripheral manifestations of anxiety, such as palpitations, tremor, and sweating. The long-acting (LA) formulations are designed to provide sustained release of the medication, allowing for convenient once-daily dosing and ensuring more consistent therapeutic effects throughout the day, which is beneficial for chronic conditions.

Uses

• Management of hypertension (high blood pressure)
• Prophylaxis of angina pectoris (chest pain)
• Control of cardiac arrhythmias (irregular heartbeats)
• Prevention of migraine headaches

Directions For Use

Take as directed by your physician, usually once or twice daily. Do not crush or chew extended-release tablets; swallow them whole.

Benefits

• Effectively lowers high blood pressure
• Reduces frequency and severity of angina attacks
• Helps regulate abnormal heart rhythms
• Prevents migraine headaches
• Alleviates symptoms of essential tremor
• Reduces physical symptoms of anxiety

Side Effects

• Bradycardia (slow heart rate)
• Fatigue or weakness
• Dizziness or lightheadedness
• Nausea or vomiting
• Diarrhea or constipation
• Cold hands and feet
• Sleep disturbances (insomnia, nightmares)
• Bronchospasm (difficulty breathing)
• Depression
• Sexual dysfunction
• Masking of hypoglycemia symptoms
• Allergic reactions (rash, itching)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can increase the hypotensive effects and enhance drowsiness.
• Pregnancy - Use with caution; consult a doctor. Propranolol crosses the placenta and may cause fetal bradycardia, hypoglycemia, or growth restriction.
• Breastfeeding - Generally considered safe, but monitor the infant for bradycardia, hypoglycemia, or respiratory distress. Consult a healthcare professional.
• Liver - Use with caution in patients with liver impairment as metabolism may be reduced, potentially increasing drug levels. Dose adjustment may be necessary.
• Kidney - Use with caution in patients with severe kidney impairment as excretion may be affected. Dose adjustment may be necessary.
• Lung - Contraindicated in patients with asthma or severe COPD due to the risk of bronchospasm. Use with extreme caution in other lung conditions.

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