Kemoplat 50mg Injection

About

Cisplatin is a highly effective platinum-based antineoplastic agent, a cornerstone in the chemotherapy regimens for a variety of solid tumors. Its mechanism of action involves the formation of DNA adducts, leading to the creation of inter- and intra-strand crosslinks within the DNA helix. These crosslinks severely disrupt critical cellular processes such as DNA replication and transcription, ultimately triggering programmed cell death (apoptosis) in rapidly proliferating cancer cells. As a cell-cycle non-specific agent, cisplatin is effective against cells in all phases of the cell cycle, contributing to its broad spectrum of activity against malignancies like testicular, ovarian, bladder, and head and neck cancers. However, its clinical utility is balanced by a significant toxicity profile, notably severe nephrotoxicity, ototoxicity, and profound nausea and vomiting, which necessitate meticulous patient monitoring, aggressive hydration, and antiemetic prophylaxis during treatment.

Uses

• Treatment of testicular cancer.
• Management of ovarian cancer.
• Therapy for bladder cancer.
• Treatment of head and neck cancers.

Directions For Use

Administer intravenously under strict medical supervision. Hydration is crucial before and after infusion.

Benefits

• Effective against various solid tumors.
• Induces cancer cell apoptosis.
• Often used in combination regimens.
• Can achieve significant tumor regression.
• Improves survival in certain cancers.
• Well-established chemotherapy agent.

Side Effects

• Severe nausea and vomiting
• Nephrotoxicity (kidney damage)
• Ototoxicity (hearing loss)
• Myelosuppression (bone marrow suppression)
• Peripheral neuropathy
• Electrolyte disturbances
• Anaphylactic reactions
• Fatigue
• Hair loss (alopecia)
• Diarrhea
• Stomatitis
• Injection site reactions

Safety Measures

• Alcohol - Avoid alcohol due to potential for increased gastrointestinal upset and liver strain.
• Pregnancy - Highly teratogenic; absolutely contraindicated. Effective contraception is essential.
• Breastfeeding - Contraindicated; drug passes into breast milk and is harmful to infant.
• Liver - Use with caution; monitor liver function tests closely.
• Kidney - Major toxicity is nephrotoxicity; contraindicated in severe renal impairment. Pre-hydration is critical.
• Lung - Rare cases of pulmonary fibrosis reported; monitor for respiratory symptoms.

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