About
Pregabalin Sustained Release (SR) 450mg is an extended-release formulation of pregabalin, an alpha-2-delta ligand. It is designed to provide a prolonged therapeutic effect by slowly releasing the active ingredient over time, allowing for less frequent dosing compared to immediate-release formulations. Its mechanism of action involves binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which modulates the release of excitatory neurotransmitters like glutamate, noradrenaline, and substance P. This action reduces neuronal hyperexcitability, contributing to its analgesic and anticonvulsant properties. The sustained-release profile helps maintain more consistent plasma concentrations, potentially improving patient adherence and reducing fluctuations in symptom control, particularly beneficial for chronic conditions requiring stable medication levels throughout the day.
Uses
- Management of neuropathic pain
- Adjunctive therapy for partial onset seizures
- Treatment of generalized anxiety disorder
- Management of fibromyalgia
Directions For Use
Take orally once daily, preferably with the evening meal. Swallow the tablet whole; do not crush, chew, or split.
Benefits
- Provides sustained relief from neuropathic pain with once-daily dosing
- Helps maintain consistent drug levels, reducing symptom fluctuations
- Improves patient adherence due to simplified dosing regimen
- Effective in controlling partial onset seizures
- Alleviates symptoms of generalized anxiety disorder
- Reduces pain and improves sleep in fibromyalgia patients
Side Effects
- Dizziness
- Somnolence (sleepiness)
- Peripheral edema (swelling)
- Weight gain
- Blurred vision
- Dry mouth
- Difficulty concentrating
- Ataxia (impaired coordination)
- Fatigue
- Headache
- Nausea
- Constipation
Safety Measures
- Alcohol - Avoid alcohol consumption as it can intensify central nervous system depressant effects like dizziness and drowsiness.
- Pregnancy - Use with caution; potential risks to the fetus exist. Consult a doctor to weigh benefits against risks.
- Breastfeeding - Not recommended as pregabalin is excreted in breast milk and may cause sedation in infants.
- Liver - Generally safe, but caution is advised in severe hepatic impairment. Dose adjustment is typically not required.
- Kidney - Requires dose adjustment in patients with impaired renal function due to renal excretion.
- Lung - Use with caution in patients with respiratory depression, especially when co-administered with other CNS depressants.
Disclaimer
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| Shop Location | Assam, India |
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