Libset 250mg Tablet

About

Chlordiazepoxide is a well-established benzodiazepine derivative, widely recognized for its potent anxiolytic, sedative, hypnotic, and skeletal muscle relaxant properties. Its therapeutic effects are mediated by enhancing the activity of gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter within the central nervous system. By binding to specific sites on the GABA-A receptor complex, chlordiazepoxide potentiates GABAergic inhibition, leading to a significant reduction in neuronal excitability. This results in a profound calming effect on the brain and spinal cord. It is particularly efficacious in the acute management of severe anxiety disorders, the symptomatic relief of acute alcohol withdrawal syndrome, and for alleviating pre-operative apprehension. The drug's relatively long half-life contributes to its sustained therapeutic action, providing prolonged relief from symptoms.

Uses

• Anxiety disorders
• Acute alcohol withdrawal syndrome
• Pre-operative apprehension and anxiety
• Muscle spasms (adjunctive therapy)

Directions For Use

Take orally as directed by your doctor. Dosage varies based on condition and patient response. Do not exceed prescribed dose.

Benefits

• Effective anxiolytic
• Reduces symptoms of alcohol withdrawal
• Provides sedation and muscle relaxation
• Relieves pre-operative anxiety
• Relatively long duration of action
• Can improve sleep in anxious patients

Side Effects

• Drowsiness
• Sedation
• Dizziness
• Ataxia (impaired coordination)
• Confusion
• Fatigue
• Blurred vision
• Nausea
• Constipation
• Memory impairment
• Paradoxical excitement (rare)
• Dependence and withdrawal symptoms

Safety Measures

• Alcohol - Avoid alcohol completely as it significantly enhances the sedative effects and increases CNS depression.
• Pregnancy - Contraindicated in pregnancy, especially in the first trimester, due to risk of congenital malformations.
• Breastfeeding - Not recommended during breastfeeding as it passes into breast milk and can cause sedation in the infant.
• Liver - Use with extreme caution in patients with severe hepatic impairment; dose reduction is often necessary.
• Kidney - Use with caution in patients with renal impairment; monitoring for accumulation is advised.
• Lung - Use with caution in patients with severe respiratory insufficiency due to risk of respiratory depression.

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