METRO 100ML

About

METRO 100ML (Metronidazole) is an intravenous solution containing the active ingredient metronidazole, a potent antibiotic and antiprotozoal agent. It is primarily used to treat serious infections caused by anaerobic bacteria and certain protozoa. Metronidazole works by disrupting the DNA of susceptible microorganisms, leading to their death. Its broad spectrum of activity against anaerobes makes it invaluable in treating a variety of severe infections, including intra-abdominal infections, pelvic inflammatory disease, bone and joint infections, and bacterial septicemia.

Administered intravenously, this formulation is particularly useful for patients who cannot take oral medication or require rapid, high concentrations of the drug, such as in critical care settings or for surgical prophylaxis. The 100ml presentation provides a convenient single dose for infusion. Due to its efficacy and established safety profile, metronidazole remains a cornerstone in the treatment of anaerobic and protozoal infections, significantly improving patient outcomes in challenging clinical scenarios.

Uses

• Treatment of severe anaerobic bacterial infections
• Management of protozoal infections (e.g., amebiasis, giardiasis)
• Surgical prophylaxis to prevent anaerobic infections
• Treatment of Clostridioides difficile-associated diarrhea (CDAD)

Directions For Use

Administer intravenously over 30-60 minutes as prescribed by a physician. Dosage and duration depend on the type and severity of infection.

Benefits

• Broad spectrum activity against anaerobic bacteria
• Effective against various protozoal infections
• Good tissue penetration, reaching infection sites effectively
• Available in IV form for critical and non-oral cases
• Reduces risk of surgical site infections
• Established efficacy in severe infections

Side Effects

• Nausea, vomiting, and abdominal cramps
• Metallic taste in the mouth
• Headache and dizziness
• Darkening of urine
• Peripheral neuropathy (with prolonged use)
• Seizures (rare)
• Allergic reactions (rash, itching, hives)
• Diarrhea
• Oral or vaginal candidiasis
• Neutropenia (decreased white blood cells)
• Pancreatitis (rare)
• Stevens-Johnson syndrome (rare)

Safety Measures

• Alcohol - Strict contraindication; causes a disulfiram-like reaction (severe nausea, vomiting, flushing, headache, palpitations). Avoid alcohol during and for at least 3 days after treatment.
• Pregnancy - Generally avoided in the first trimester; use only if clearly needed and potential benefits outweigh risks in later trimesters. Consult a physician.
• Breastfeeding - Excreted into breast milk; consider temporary interruption of breastfeeding or an alternative medication. Consult a physician.
• Liver - Use with caution in severe hepatic impairment; dose adjustment may be necessary due to impaired metabolism.
• Kidney - Use with caution in severe renal impairment; dose adjustment may be necessary, especially for patients on dialysis.
• Lung - No specific lung-related contraindications, but monitor for systemic effects in patients with compromised respiratory function.

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