About
Telmisartan is an angiotensin II receptor blocker (ARB) that selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle and the adrenal gland. Angiotensin II is a potent vasoconstrictor and a primary mediator of the renin-angiotensin-aldosterone system (RAAS), which plays a critical role in blood pressure regulation and the pathophysiology of hypertension. By blocking the AT1 receptor, telmisartan inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and a reduction in blood pressure.
This action helps to lower both systolic and diastolic blood pressure, reducing the workload on the heart and decreasing the risk of cardiovascular events such as stroke and myocardial infarction. Telmisartan has a long duration of action, allowing for once-daily dosing, and is also known for its renoprotective effects, particularly in patients with diabetes and hypertension.
Uses
- Treatment of essential hypertension
- Reduction of cardiovascular morbidity and mortality
- Prevention of stroke and myocardial infarction
- Management of diabetic nephropathy (off-label)
Directions For Use
Take one tablet orally once daily, with or without food, as prescribed by your doctor.
Benefits
- Effectively lowers high blood pressure
- Reduces the risk of stroke
- Decreases the risk of heart attack
- Provides long-lasting blood pressure control
- Offers cardiovascular protection
- Generally well-tolerated
Side Effects
- Dizziness
- Fatigue
- Headache
- Cough
- Back pain
- Diarrhea
- Nausea
- Hypotension
- Hyperkalemia
- Angioedema (rare)
- Renal dysfunction
- Muscle cramps
Safety Measures
- Alcohol - Alcohol can enhance the hypotensive effect of telmisartan, potentially leading to increased dizziness or lightheadedness. Use with caution.
- Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to risk of fetal harm. Consult your doctor immediately if pregnant.
- Breastfeeding - Not recommended during breastfeeding as telmisartan may pass into breast milk. Consult your doctor.
- Liver - Use with caution in patients with severe hepatic impairment or biliary obstructive disorders. Dose adjustment may be necessary.
- Kidney - Monitor renal function regularly, especially in patients with renal artery stenosis or severe renal impairment.
- Lung - No specific contraindications or precautions related to lung conditions are generally noted.
Disclaimer
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