MONUROL 8G 1S

About

Fosfomycin 8g is a unique broad-spectrum antibiotic specifically designed for the treatment of uncomplicated urinary tract infections (UTIs) in women. Its mechanism of action involves inhibiting an early stage of bacterial cell wall synthesis by inactivating the enzyme enolpyruvyl transferase. This distinct mode of action minimizes cross-resistance with other antibiotic classes, making it effective against a range of susceptible bacteria. The medication is rapidly absorbed and achieves high concentrations in the urine, where it exerts its bactericidal effect against common uropathogens like E. coli, Klebsiella, and Proteus. Its single-dose regimen offers significant convenience and promotes patient adherence, making it a highly effective and practical choice for acute cystitis and improving patient outcomes.

Uses

• Acute uncomplicated cystitis
• Asymptomatic bacteriuria (in specific cases)
• Prophylaxis for transurethral procedures
• Treatment of susceptible bacterial UTIs

Directions For Use

Dissolve the entire contents of one sachet in 90-120 ml (half a glass) of cold water and drink immediately. Take as a single dose, preferably at bedtime after emptying the bladder.

Benefits

• Single-dose treatment
• Effective against common UTI pathogens
• Good penetration into urinary tract
• Low resistance rates
• Generally well-tolerated
• Convenient for patients

Side Effects

• Diarrhea
• Nausea
• Headache
• Dizziness
• Abdominal pain
• Dyspepsia
• Vaginitis
• Rash
• Asthenia
• Back pain
• Pharyngitis
• Rhinitis

Safety Measures

• Alcohol - No specific contraindication with alcohol, but it's generally advisable to avoid excessive intake during infection.
• Pregnancy - Generally considered safe for use in pregnancy for uncomplicated UTIs, but always consult a healthcare provider.
• Breastfeeding - Fosfomycin is excreted in breast milk in small amounts; generally considered compatible, but monitor infant for diarrhea.
• Liver - No specific dose adjustment is typically required for patients with liver conditions, as it is primarily excreted renally.
• Kidney - Use with caution in severe renal impairment (creatinine clearance <10 mL/min) as accumulation may occur; dose adjustment may be needed.
• Lung - No specific concerns for patients with lung conditions, as its primary action is in the urinary tract.

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