Myelostat 500mg Capsule

About

Myelostat 500mg Capsule contains Hydroxyurea, an antineoplastic agent that functions by inhibiting ribonucleotide reductase, a key enzyme crucial for DNA synthesis. This inhibition leads to cell cycle arrest in the S-phase, preventing the proliferation of rapidly dividing cells, particularly malignant ones. It is extensively utilized in the management of various myeloproliferative neoplasms, such as chronic myeloid leukemia, polycythemia vera, and essential thrombocythemia, where it effectively reduces elevated blood cell counts and controls disease progression. Furthermore, its unique mechanism involves increasing the production of fetal hemoglobin, which is therapeutically beneficial in sickle cell disease. By elevating fetal hemoglobin levels, Myelostat helps to reduce the frequency of painful vaso-occlusive crises and acute chest syndrome, significantly improving the quality of life for affected patients. Regular monitoring of blood counts is essential during treatment due to its myelosuppressive effects.

Uses

• Chronic Myeloid Leukemia (CML)
• Polycythemia Vera
• Essential Thrombocythemia
• Sickle Cell Anemia

Directions For Use

Take orally as directed by your physician, usually once daily. Swallow the capsule whole with water.

Benefits

• Reduces elevated blood cell counts.
• Manages symptoms of myeloproliferative disorders.
• Decreases frequency of sickle cell crises.
• Improves quality of life in chronic conditions.
• Oral administration for convenience.
• Well-established efficacy in its indications.

Side Effects

• Bone marrow suppression (leukopenia, thrombocytopenia, anemia)
• Nausea and vomiting
• Diarrhea
• Stomatitis
• Skin hyperpigmentation
• Skin ulcers (especially leg ulcers)
• Alopecia
• Fever
• Anorexia
• Dizziness
• Headache
• Elevated liver enzymes

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to teratogenic effects; effective contraception is essential for both male and female patients.
• Breastfeeding - Not recommended during breastfeeding as it is excreted in breast milk and can cause serious adverse effects in the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustment may be necessary.
• Kidney - Use with caution in patients with renal impairment; dose reduction is typically required.
• Lung - Rare cases of interstitial lung disease have been reported; monitor for new or worsening pulmonary symptoms.

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