NAB TORTAXEL 100 MG INJ. VIAL.

About

NAB TORTAXEL is an innovative albumin-bound formulation of paclitaxel, a well-known taxane-class antineoplastic agent. This unique formulation delivers paclitaxel without the need for solvent-based carriers, such as Cremophor EL, which are often associated with severe hypersensitivity reactions and necessitate extensive premedication. The mechanism of action of NAB TORTAXEL involves binding to tubulin, promoting the assembly of microtubules, and simultaneously inhibiting their depolymerization. This stabilization of microtubules leads to the disruption of the normal dynamic equilibrium of the mitotic spindle, arresting cancer cells in the G2/M phase of the cell cycle and ultimately inducing apoptosis. The albumin-bound technology is designed to enhance drug delivery to tumors by utilizing the albumin-mediated transport pathway, potentially improving efficacy and reducing certain toxicities compared to conventional paclitaxel, making it a valuable therapeutic option for various solid tumors, including metastatic breast cancer, non-small cell lung cancer, and pancreatic adenocarcinoma.

Uses

• Treatment of metastatic breast cancer.
• Management of non-small cell lung cancer.
• Therapy for metastatic pancreatic adenocarcinoma.
• For patients who have failed prior therapies.

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion schedule are determined by the patient's condition and body surface area.

Benefits

• Effective against a range of solid tumors.
• Reduced incidence of hypersensitivity reactions.
• No need for premedication with corticosteroids.
• Improved tumor penetration due to albumin binding.
• Can be used in patients intolerant to solvent-based taxanes.
• Contributes to disease control and improved outcomes.

Side Effects

• Bone marrow suppression (neutropenia, anemia)
• Peripheral neuropathy (sensory and motor)
• Fatigue and asthenia
• Alopecia (hair loss)
• Nausea and vomiting
• Diarrhea
• Arthralgia (joint pain)
• Myalgia (muscle pain)
• Infections
• Edema (swelling)
• Rash
• Mucositis

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects or interact with the medication.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm; effective contraception is required.
• Breastfeeding - Not recommended during breastfeeding as the drug may be excreted in breast milk and harm the infant.
• Liver - Use with caution and potential dose adjustment in patients with hepatic impairment due to increased risk of toxicity.
• Kidney - Administer with caution in patients with renal impairment; monitor kidney function closely during treatment.
• Lung - Rarely associated with interstitial lung disease; monitor for new or worsening respiratory symptoms.

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