Neomib 2mg Injection

About

Bortezomib is a first-in-class proteasome inhibitor, a targeted therapy crucial for the treatment of multiple myeloma and mantle cell lymphoma. It works by reversibly inhibiting the 26S proteasome, a multi-protein complex responsible for degrading ubiquitinated proteins within cells. By blocking the proteasome, bortezomib causes an accumulation of misfolded and unwanted proteins, leading to endoplasmic reticulum stress, activation of pro-apoptotic pathways, and ultimately, programmed cell death in cancer cells. This selective action against malignant cells, while sparing normal cells to a greater extent, makes it a highly effective agent, often used in combination with other drugs to improve patient outcomes and achieve deeper responses.

Uses

• Multiple myeloma
• Mantle cell lymphoma
• Relapsed/refractory multiple myeloma
• Newly diagnosed multiple myeloma

Directions For Use

Administered subcutaneously or intravenously by a healthcare professional, typically twice weekly for a period.

Benefits

• Targets cancer cell proteasomes
• Induces apoptosis in cancer cells
• Effective in multiple myeloma
• Effective in mantle cell lymphoma
• Improved response rates
• Can be used in combination therapy

Side Effects

• Peripheral neuropathy
• Thrombocytopenia
• Neutropenia
• Fatigue
• Nausea
• Diarrhea
• Constipation
• Vomiting
• Fever
• Rash
• Hypotension
• Herpes zoster reactivation

Safety Measures

• Alcohol - Avoid or limit alcohol, especially if experiencing peripheral neuropathy, as it may worsen symptoms.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm; use effective contraception.
• Breastfeeding - Avoid breastfeeding during treatment and for a period after the last dose.
• Liver - Use with caution in hepatic impairment; dose adjustment is often required.
• Kidney - Use with caution in renal impairment; dose adjustment may be necessary.
• Lung - Monitor for acute diffuse infiltrative pulmonary disease, which can be severe.

Disclaimer

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