About

Filgrastim is a recombinant human granulocyte colony-stimulating factor (G-CSF) used to stimulate the production of neutrophils in the bone marrow. It is primarily indicated for the treatment of neutropenia, a condition characterized by abnormally low levels of neutrophils, which are crucial white blood cells for fighting infection. Filgrastim is commonly used in patients undergoing myelosuppressive chemotherapy for nonmyeloid malignancies, to reduce the incidence of febrile neutropenia. It is also used in patients with severe chronic neutropenia, for mobilization of peripheral blood progenitor cells for autologous or allogeneic transplantation, and in patients with acute myeloid leukemia receiving induction or consolidation chemotherapy. By increasing neutrophil counts, Filgrastim helps to reduce the risk and severity of infections, thereby improving patient outcomes and allowing for timely administration of chemotherapy cycles.

Uses

Reduction of febrile neutropenia incidence.
Treatment of severe chronic neutropenia.
Mobilization of peripheral blood progenitor cells.
Neutrophil recovery after bone marrow transplant.

Directions For Use

Administer subcutaneously or intravenously as directed by a healthcare professional. Dosage is based on body weight and indication.

Benefits

Significantly reduces infection risk in neutropenia.
Allows for on-schedule chemotherapy administration.
Enhances recovery of neutrophil counts.
Improves patient safety during chemotherapy.
Effective in various neutropenic conditions.
Available in convenient pre-filled syringes.

Side Effects

Bone pain
Myalgia
Headache
Fatigue
Nausea
Diarrhea
Alopecia
Splenomegaly
Injection site reactions
Thrombocytopenia
Leukocytosis
Allergic reactions

Safety Measures

Alcohol - No specific interaction, but general health advice to limit alcohol applies.
Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus; consult a physician.
Breastfeeding - Exercise caution; it is unknown if Filgrastim is excreted in human milk. Consult a doctor.
Liver - No specific dose adjustment needed for hepatic impairment, but monitor overall health.
Kidney - No specific dose adjustment needed for renal impairment, but monitor overall health.
Lung - Monitor for acute respiratory distress syndrome (ARDS) or alveolar hemorrhage.

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