Oncovorin 50mg Injection

About

Oncovorin Injection, containing leucovorin calcium, is a formyl derivative of tetrahydrofolic acid, which is a metabolically active form of folic acid. It is not a cytotoxic agent itself but plays a crucial role in oncology as a "rescue" therapy and a potentiator of other chemotherapy drugs. Leucovorin is primarily used to counteract the toxic effects of folic acid antagonists like methotrexate, by providing a source of reduced folates that bypass the enzymatic block caused by the antagonist, thereby protecting healthy cells from damage.

Additionally, Oncovorin is widely utilized to enhance the cytotoxic effects of fluorouracil in the treatment of various gastrointestinal cancers, particularly colorectal cancer. It stabilizes the binding of fluorouracil's active metabolite to thymidylate synthase, leading to prolonged inhibition of DNA synthesis and increased tumor cell death. Its administration is typically intravenous, and precise timing and dosing are critical for its therapeutic efficacy and safety.

Uses

• Leucovorin rescue after high-dose methotrexate therapy.
• Potentiation of fluorouracil in colorectal cancer.
• Treatment of megaloblastic anemia due to folate deficiency.
• Antidote for other folate antagonists (e.g., trimethoprim).

Directions For Use

Oncovorin Injection is administered intravenously by a healthcare professional. The dosage and schedule are highly dependent on the specific indication and the patient's clinical condition.

Benefits

• Effectively reduces methotrexate toxicity.
• Significantly enhances fluorouracil efficacy.
• Essential component in certain chemotherapy regimens.
• Well-tolerated with a generally favorable safety profile.
• Provides crucial cellular protection.
• Versatile in various clinical settings.

Side Effects

• Allergic reactions (rare)
• Fever
• Nausea
• Vomiting
• Diarrhea
• Stomatitis (when used with fluorouracil)
• Rash
• Pruritus
• Insomnia
• Agitation
• Depression
• Seizures (rare, high doses)
• Increased fluorouracil toxicity (if not dosed correctly)

Safety Measures

• Alcohol - Generally, there is no direct interaction with alcohol. However, excessive alcohol consumption can worsen folate deficiency, potentially impacting the drug's efficacy in certain contexts.
• Pregnancy - Oncovorin is generally considered safe for use during pregnancy when clinically indicated, particularly for methotrexate rescue. However, always consult a physician.
• Breastfeeding - Use with caution during breastfeeding. While generally considered compatible, monitor the infant for any adverse effects and consult a healthcare provider.
• Liver - Use with caution in patients with liver conditions. No specific dose adjustment is usually needed, but liver function should be monitored, especially with concomitant hepatotoxic drugs.
• Kidney - Use with caution in patients with kidney conditions. No specific dose adjustment is typically required, but monitor renal function, especially in cases of impaired methotrexate elimination.
• Lung - No specific lung-related safety concerns are directly associated with Oncovorin itself.

Disclaimer

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