Oxemia 100mg Tablet

About

Oxemia 100mg Tablet contains deferiprone, an oral iron chelator indicated for the treatment of iron overload in patients with thalassemia syndromes and other chronic anemias who receive regular blood transfusions. The continuous need for transfusions leads to an accumulation of excess iron, which can be highly toxic to various organs, including the heart, liver, and endocrine glands. Deferiprone works by forming a stable, non-toxic complex with ferric iron (Fe3+) in the body, facilitating its excretion primarily through the urine.

This chelation therapy is crucial for preventing and managing the severe complications associated with iron overload, thereby improving patient morbidity and mortality. Close monitoring of hematological parameters, particularly neutrophil counts, and organ function is essential throughout the treatment course to detect and manage potential adverse effects, ensuring the safety and efficacy of the therapy.

Uses

• Treatment of iron overload in thalassemia major.
• Management of iron overload in other chronic anemias.
• When deferoxamine therapy is contraindicated or inadequate.
• To prevent organ damage from excess iron accumulation.

Directions For Use

Take the tablet orally, usually two to three times daily, as directed by your physician. It can be taken with or without food.

Benefits

• Effectively reduces excess iron levels.
• Oral formulation offers convenience over injections.
• Helps prevent organ damage from iron overload.
• Improves cardiac function in some patients.
• Can be used in combination with other chelators.
• Well-established safety profile with monitoring.

Side Effects

• Nausea
• Vomiting
• Abdominal pain
• Diarrhea
• Arthralgia (joint pain)
• Neutropenia (low white blood cell count)
• Agranulocytosis (severe neutropenia)
• Reddish-brown urine discoloration
• Increased liver enzymes
• Headache
• Dizziness
• Skin rash

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of liver toxicity, which is a concern with iron overload and deferiprone.
• Pregnancy - Contraindicated. Deferiprone can cause fetal harm. Effective contraception is required during treatment and for a period after.
• Breastfeeding - Contraindicated. It is unknown if deferiprone is excreted in human milk; discontinue breastfeeding during treatment.
• Liver - Use with caution. Monitor liver function tests regularly as deferiprone can cause elevated liver enzymes. Dose adjustment may be needed.
• Kidney - Use with caution. Monitor kidney function regularly. Dose adjustment may be necessary in patients with severe renal impairment.
• Lung - No specific precautions for lung conditions are typically associated with deferiprone.

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