Oxiplat 50mg Injection

About

Oxiplat 50mg Injection contains Oxaliplatin, a platinum-based antineoplastic agent primarily used in the treatment of various cancers, particularly colorectal cancer. It functions by forming DNA adducts, which interfere with DNA replication and transcription, ultimately leading to programmed cell death in rapidly dividing cancer cells. This mechanism makes it a potent cytotoxic agent. It is typically administered intravenously, often in combination with other chemotherapeutic agents like fluoropyrimidines (e.g., 5-fluorouracil and leucovorin) as part of established regimens such as FOLFOX. Its efficacy lies in its ability to disrupt the cellular machinery essential for cancer cell proliferation and survival.

The drug's clinical utility extends to both adjuvant settings, where it helps prevent recurrence after primary tumor removal, and in the treatment of metastatic disease to control tumor growth and improve patient outcomes. Due to its potent nature, administration requires careful monitoring by healthcare professionals to manage potential side effects, with peripheral neuropathy being a notable concern. Regular assessment of patient tolerance and disease response is crucial throughout the treatment course.

Uses

• Adjuvant treatment of stage III colon cancer.
• Treatment of metastatic colorectal cancer.
• Often used in combination chemotherapy regimens.
• Palliative treatment for advanced gastrointestinal cancers.

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion rate are determined by the patient's body surface area, medical condition, and treatment regimen.

Benefits

• Effective against various solid tumors, particularly colorectal cancer.
• Improves progression-free survival in metastatic settings.
• Enhances overall survival when used as adjuvant therapy.
• Part of established and effective chemotherapy regimens (e.g., FOLFOX).
• Can be used in both adjuvant and palliative treatment settings.
• Offers a targeted approach to inhibit cancer cell growth and spread.

Side Effects

• Peripheral neuropathy (numbness, tingling)
• Nausea and vomiting
• Diarrhea
• Fatigue and weakness
• Myelosuppression (low blood counts)
• Stomatitis or mucositis
• Hypersensitivity reactions (rash, itching)
• Abdominal pain
• Elevated liver enzymes
• Renal dysfunction
• Hair thinning (alopecia)
• Taste disturbance

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or potentially increase liver toxicity associated with the medication.
• Pregnancy - Oxaliplatin is contraindicated in pregnancy due to its potential to cause fetal harm. Effective contraception must be used by both male and female patients during and for a period after treatment.
• Breastfeeding - Breastfeeding is not recommended during treatment with Oxaliplatin and for a period thereafter, due to the potential for serious adverse effects in the breastfed infant.
• Liver - Use with caution in patients with pre-existing liver impairment. Liver function should be closely monitored, and dose adjustments may be necessary based on the severity of hepatic dysfunction.
• Kidney - Use with caution in patients with renal impairment. Dose adjustments are often required based on creatinine clearance, and renal function should be regularly monitored throughout treatment.
• Lung - Rare but serious pulmonary toxicity, including interstitial lung disease, can occur. Monitor for new or worsening respiratory symptoms; use with caution in patients with pre-existing lung conditions.

Disclaimer

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