OXALTOR 100MG INJ VIAL

About

OXALTOR is a platinum-based antineoplastic agent, a third-generation compound that plays a critical role in the treatment of various cancers, most notably colorectal cancer. Its mechanism of action involves the formation of DNA adducts and both inter- and intra-strand cross-links within the DNA helix. These platinum-DNA complexes distort the DNA structure, preventing essential cellular processes such as DNA replication and transcription. This extensive DNA damage triggers cell cycle arrest and ultimately leads to programmed cell death (apoptosis) in rapidly dividing cancer cells. Unlike earlier platinum agents like cisplatin and carboplatin, OXALTOR exhibits a distinct toxicity profile, particularly characterized by a unique form of peripheral neuropathy. It is frequently administered intravenously in combination with fluoropyrimidines (e.g., 5-FU and leucovorin) as part of established regimens like FOLFOX, significantly improving disease-free and overall survival rates in both adjuvant and metastatic settings.

Uses

• Adjuvant treatment of stage III colon cancer.
• Treatment of metastatic colorectal cancer.
• Management of advanced gastric cancer.
• Therapy for pancreatic adenocarcinoma.

Directions For Use

Administered intravenously as an infusion by a healthcare professional. Dosage is calculated based on body surface area and specific treatment regimen.

Benefits

• Highly effective against colorectal cancer.
• Improves disease-free and overall survival.
• Often used in synergistic combination regimens.
• Well-established efficacy in metastatic settings.
• Distinct toxicity profile compared to other platinum agents.
• Contributes to tumor regression and symptom control.

Side Effects

• Peripheral neuropathy (acute and chronic)
• Nausea and vomiting
• Diarrhea
• Fatigue and asthenia
• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Stomatitis (mouth sores)
• Abdominal pain
• Allergic reactions (rash, dyspnea, hypotension)
• Elevated liver enzymes
• Ototoxicity (hearing impairment)
• Nephrotoxicity (kidney damage)
• Anorexia

Safety Measures

• Alcohol - No specific contraindication, but moderation is advised; discuss with your doctor.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm; use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may be excreted in breast milk.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function closely.
• Kidney - Dose adjustment may be necessary for patients with severe renal impairment; monitor kidney function.
• Lung - Rarely associated with interstitial lung disease; monitor for new or worsening respiratory symptoms.

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