OXALTERO 50MG INJ VIAL

About

Oxaliplatin is a third-generation platinum-based antineoplastic agent widely used in the treatment of various cancers, particularly colorectal cancer. Its mechanism of action involves the formation of DNA adducts, primarily inter- and intra-strand cross-links, which inhibit DNA replication and transcription. This leads to DNA damage, cell cycle arrest, and ultimately apoptosis in rapidly proliferating cancer cells. Unlike cisplatin and carboplatin, oxaliplatin has a distinct spectrum of activity and a different toxicity profile, notably less nephrotoxicity and ototoxicity. It is often administered intravenously in combination with fluoropyrimidines (e.g., 5-FU and leucovorin) as part of the FOLFOX regimen, enhancing its cytotoxic effects. Its efficacy in metastatic colorectal cancer and as adjuvant therapy has made it a cornerstone in oncology.

Uses

• Metastatic colorectal cancer
• Adjuvant treatment of colon cancer
• Gastric cancer (off-label)
• Pancreatic cancer (off-label)

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion schedule are tailored to the patient's condition and treatment protocol.

Benefits

• Key component in effective colorectal cancer regimens.
• Demonstrates synergistic effects with fluoropyrimidines.
• Improved survival rates in metastatic and adjuvant settings.
• Lower incidence of nephrotoxicity compared to other platinum agents.
• Manageable toxicity profile with appropriate supportive care.
• Established efficacy in various solid tumors.

Side Effects

• Peripheral neuropathy (acute and chronic)
• Nausea and vomiting
• Diarrhea
• Myelosuppression (thrombocytopenia, neutropenia)
• Fatigue
• Stomatitis/mucositis
• Hypersensitivity reactions
• Hepatotoxicity
• Elevated liver enzymes
• Anorexia
• Abdominal pain
• Dysgeusia (taste disturbance)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may worsen gastrointestinal side effects or liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to potential for severe fetal harm. Use effective contraception during and for at least one month after treatment.
• Breastfeeding - Not recommended during breastfeeding as oxaliplatin may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function closely as dose adjustments may be needed.
• Kidney - Use with caution in patients with severe renal impairment; dose reduction may be necessary.
• Lung - Rare cases of interstitial lung disease or pulmonary fibrosis have been reported; monitor for respiratory symptoms.

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