Oxpla 50mg Injection

About

Oxpla 50mg Injection contains Oxaliplatin, a third-generation platinum-based antineoplastic agent. It works by forming DNA adducts, primarily inter- and intra-strand cross-links, which inhibit DNA replication and transcription. This ultimately leads to cell cycle arrest and apoptosis (programmed cell death) in cancer cells. Unlike cisplatin and carboplatin, oxaliplatin has a distinct mechanism of action and a different toxicity profile, notably less nephrotoxicity and ototoxicity. It is highly effective against colorectal cancer and is often used in combination with fluoropyrimidines (e.g., 5-fluorouracil and leucovorin) in regimens like FOLFOX. Oxaliplatin's efficacy extends to both adjuvant and metastatic settings, improving patient outcomes in gastrointestinal malignancies.

Uses

• Colorectal cancer (adjuvant and metastatic)
• Gastric cancer
• Pancreatic cancer
• Esophageal cancer

Directions For Use

Administer intravenously over 2-6 hours, typically every 2 weeks, under medical supervision. Ensure proper hydration before and after infusion.

Benefits

• Effective against colorectal cancer.
• Forms DNA adducts, inhibiting cancer cell growth.
• Less nephrotoxic than other platinum agents.
• Often used in combination regimens (e.g., FOLFOX).
• Improves progression-free and overall survival.
• Part of standard treatment protocols for GI cancers.

Side Effects

• Peripheral neuropathy (acute and chronic)
• Myelosuppression (thrombocytopenia, neutropenia)
• Nausea and vomiting (severe)
• Diarrhea
• Fatigue
• Stomatitis
• Hypersensitivity reactions
• Liver enzyme elevation
• Ototoxicity (less common than cisplatin)
• Nephrotoxicity (less common than cisplatin)
• Laryngopharyngeal dysesthesia (cold-induced)
• Abdominal pain

Safety Measures

• Alcohol - Avoid or limit alcohol, as it may exacerbate gastrointestinal side effects or liver toxicity, which can be associated with this medication.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm. Effective contraception is required during treatment and for a period after.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant; it is unknown if the drug is excreted in human milk.
• Liver - Use with caution in hepatic impairment; monitor liver function closely as dose adjustments may be necessary.
• Kidney - Use with caution in renal impairment; dose adjustments may be necessary based on creatinine clearance.
• Lung - Rarely, interstitial lung disease or pulmonary fibrosis can occur; monitor for new or worsening respiratory symptoms.

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