PAC MED 100mg Injection

About

PAC MED 100mg Injection contains Paclitaxel, an antineoplastic agent from the taxane family. Its mechanism of action involves promoting the assembly of microtubules from tubulin dimers and stabilizing them by preventing depolymerization. This stabilization inhibits the dynamic reorganization of the microtubule network, which is crucial for vital cellular functions like mitosis and interphase transport. Consequently, cancer cells are arrested in the G2/M phase of the cell cycle, leading to apoptosis (programmed cell death). The 100mg dose is often utilized in weekly regimens or for specific tumor types where a lower, more frequent dose is preferred to manage toxicity while maintaining efficacy. It is administered intravenously as part of a chemotherapy protocol.

Uses

• Metastatic breast cancer (weekly regimen)
• Advanced ovarian cancer (weekly regimen)
• Non-small cell lung cancer
• Gastric cancer (in combination)

Directions For Use

Administer intravenously over 1-3 hours, typically weekly, after appropriate premedication. Ensure proper hydration and monitoring during infusion.

Benefits

• Effective against a broad range of solid tumors.
• Weekly dosing may improve tolerability for some patients.
• Induces cell cycle arrest and apoptosis.
• Can be used in various combination therapies.
• Well-established efficacy in oncology.
• May improve patient outcomes in advanced cancers.

Side Effects

• Myelosuppression (neutropenia)
• Peripheral neuropathy
• Hypersensitivity reactions
• Alopecia
• Nausea and vomiting
• Myalgia/arthralgia
• Diarrhea
• Mucositis
• Bradycardia
• Hypotension
• Liver enzyme elevation
• Fatigue

Safety Measures

• Alcohol - Avoid alcohol, especially if liver function is compromised, as it may exacerbate liver toxicity, a known side effect of Paclitaxel.
• Pregnancy - Contraindicated in pregnancy due to significant potential for fetal harm. Effective contraception is mandatory during treatment and for a period after.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant; the drug may be excreted in human milk.
• Liver - Use with caution in hepatic impairment; dose adjustments are often necessary due to hepatic metabolism.
• Kidney - Use with caution in renal impairment; monitor kidney function, though renal excretion is a minor elimination pathway.
• Lung - Rarely, interstitial pneumonitis or pulmonary fibrosis can occur; monitor for new or worsening respiratory symptoms.

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