NAB Celtax 100mg Injection

About

Nab-paclitaxel is an albumin-bound form of paclitaxel, a highly effective microtubule inhibitor used in the treatment of various cancers. This innovative formulation works by disrupting the normal function of microtubules, which are critical cellular structures involved in cell division and other vital processes. By interfering with microtubule dynamics, nab-paclitaxel induces cell cycle arrest and ultimately leads to apoptosis, or programmed cell death, in rapidly proliferating cancer cells. The unique albumin-bound delivery system allows for enhanced drug accumulation within tumor tissues, potentially increasing its therapeutic efficacy while minimizing systemic toxicity. Furthermore, this formulation often eliminates the need for pre-medication with corticosteroids and antihistamines, which are typically required with conventional solvent-based paclitaxel to prevent hypersensitivity reactions. It represents a significant advancement in chemotherapy, offering a potent antineoplastic option for patients with specific solid tumors.

Uses

• Metastatic breast cancer
• Advanced non-small cell lung cancer
• Metastatic pancreatic adenocarcinoma
• Other solid tumors as per clinical guidelines

Directions For Use

Administered intravenously by a healthcare professional. Dosage and schedule are determined by the patient's condition and response.

Benefits

• Effective against various solid tumors.
• Albumin-bound formulation may reduce hypersensitivity risk.
• Potentially higher tumor drug concentration.
• Improved patient tolerability compared to solvent-based paclitaxel.
• Does not require steroid pre-medication.
• Offers a targeted delivery mechanism.

Side Effects

• Peripheral neuropathy
• Myelosuppression (low blood counts)
• Fatigue
• Nausea and vomiting
• Hair loss (alopecia)
• Diarrhea
• Muscle and joint pain
• Hypersensitivity reactions
• Infection risk
• Liver enzyme elevation
• Fluid retention
• Mouth sores (mucositis)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate side effects like liver issues or nausea.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm. Effective contraception is essential for both male and female patients.
• Breastfeeding - Not recommended during breastfeeding due to the risk of serious adverse reactions in the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary.
• Kidney - Use with caution in patients with renal impairment; monitoring is advised.
• Lung - Monitor for signs of pneumonitis or interstitial lung disease, especially in patients with pre-existing lung conditions.

Disclaimer

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