Lupiparp 100mg Tablet

About

Lupiparp 100mg Tablet is a targeted anticancer agent classified as a poly(ADP-ribose) polymerase (PARP) inhibitor. It operates by interfering with the cellular machinery responsible for repairing damaged DNA, specifically in cancer cells that have existing defects in their DNA repair pathways, such as those with BRCA1/2 mutations. By blocking PARP enzymes, Lupiparp prevents the repair of single-strand DNA breaks, leading to an accumulation of irreparable DNA damage within the cancer cells. This ultimately triggers programmed cell death (apoptosis), selectively targeting malignant cells while largely sparing healthy ones. It is a crucial component of precision oncology, particularly for patients with specific genetic predispositions or homologous recombination deficiency, offering a tailored approach to treatment that capitalizes on the unique vulnerabilities of tumor cells.

Uses

• Maintenance therapy for recurrent ovarian, fallopian tube, or primary peritoneal cancer.
• Treatment of advanced breast cancer with germline BRCA mutations.
• Management of metastatic castration-resistant prostate cancer with HRR gene mutations.
• Therapy for metastatic pancreatic adenocarcinoma with BRCA mutations.

Directions For Use

Take Lupiparp 100mg Tablet orally twice daily, with or without food, as directed by your healthcare provider. Swallow the tablets whole; do not crush, chew, or split them.

Benefits

• Selectively targets cancer cells with DNA repair deficiencies.
• Improves progression-free survival in specific cancer types.
• Effective in patients with BRCA1/2 mutations.
• Offers a targeted, oral treatment option.
• Can be used as maintenance therapy to extend remission.
• Part of a personalized approach to cancer treatment.

Side Effects

• Nausea
• Fatigue
• Vomiting
• Anemia
• Diarrhea
• Decreased appetite
• Abdominal pain
• Myelosuppression
• Headache
• Dyspepsia
• Rash
• Musculoskeletal pain

Safety Measures

• Alcohol - Limit or avoid alcohol consumption as it may exacerbate gastrointestinal side effects or interact with the medication.
• Pregnancy - Lupiparp is contraindicated during pregnancy due to potential embryofetal toxicity. Women of childbearing potential must use effective contraception.
• Breastfeeding - Breastfeeding is not recommended during treatment with Lupiparp and for a period after the last dose, as the drug may be excreted in breast milk.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Regular monitoring of liver function tests is advised.
• Kidney - Dose adjustments are typically required for patients with moderate to severe renal impairment. Monitor kidney function closely during therapy.
• Lung - Rare but serious cases of pneumonitis have been reported. Patients should be monitored for new or worsening respiratory symptoms.

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