Olpaza 150mg Tablet

About

Olaparib is an oral poly(ADP-ribose) polymerase (PARP) inhibitor, a targeted therapy used in the treatment of certain cancers, particularly those with BRCA gene mutations. It works by trapping PARP enzymes on DNA single-strand breaks, leading to the accumulation of DNA damage and ultimately cell death in cancer cells that have homologous recombination repair (HRR) deficiencies, such as those with BRCA1/2 mutations. This mechanism of synthetic lethality makes it highly effective in specific patient populations, offering a personalized approach to cancer treatment. It is crucial for patients to undergo genetic testing to determine eligibility for this therapy, as its efficacy is linked to the presence of these specific genetic alterations. Olaparib has demonstrated significant clinical benefits, including extended progression-free survival, in various advanced cancers like ovarian, breast, pancreatic, and prostate cancers, marking a significant advancement in precision oncology. Its oral administration also offers convenience for long-term maintenance therapy.

Uses

• Maintenance treatment of ovarian cancer.
• Treatment of HER2-negative metastatic breast cancer.
• Management of metastatic pancreatic adenocarcinoma.
• Treatment of metastatic castration-resistant prostate cancer.

Directions For Use

Take orally, usually twice daily, with or without food. Follow your doctor's specific dosing instructions.

Benefits

• Targets specific genetic mutations in cancer cells.
• Offers a personalized treatment approach.
• Can extend progression-free survival.
• Available as an oral medication, improving convenience.
• Approved for multiple cancer types with specific mutations.
• Represents a significant advance in targeted oncology.

Side Effects

• Nausea
• Fatigue
• Vomiting
• Anemia
• Diarrhea
• Decreased appetite
• Abdominal pain
• Constipation
• Dysgeusia (taste disturbance)
• Myelosuppression
• Rash
• Headache

Safety Measures

• Alcohol - Limit alcohol intake as it may worsen nausea or fatigue, common side effects of olaparib.
• Pregnancy - Contraindicated during pregnancy due to potential for embryo-fetal toxicity; use effective contraception.
• Breastfeeding - Discontinue breastfeeding during treatment and for 1 month after the last dose due to potential harm to the infant.
• Liver - Use with caution in patients with moderate hepatic impairment; no dose adjustment needed for mild impairment.
• Kidney - Dose adjustment may be required for patients with moderate or severe renal impairment.
• Lung - Monitor for new or worsening respiratory symptoms, as pneumonitis, though rare, can occur.

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