PAMORELIN LA 3.75 INJ VIAL

About

Pamorelin LA 3.75 Injection contains triptorelin, a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH). As a GnRH agonist, it initially stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), but with continuous administration, it leads to desensitization and downregulation of GnRH receptors. This results in a sustained decrease in LH and FSH secretion, subsequently reducing the production of sex hormones (testosterone in males and estrogen in females) to castration levels. This pharmacological effect is utilized in various hormone-dependent conditions where suppression of sex hormones is therapeutically beneficial. The 'LA' designation indicates a long-acting formulation, typically administered monthly, providing sustained therapeutic levels of triptorelin to maintain hormonal suppression over an extended period, thereby improving patient compliance and convenience in chronic treatment regimens.

Uses

• Treatment of prostate cancer.
• Management of endometriosis.
• Treatment of uterine fibroids.
• Management of central precocious puberty.

Directions For Use

Administer as a single intramuscular injection, typically once every four weeks, as directed by a healthcare professional. Ensure proper reconstitution before use.

Benefits

• Provides sustained hormonal suppression.
• Reduces tumor growth in hormone-sensitive cancers.
• Alleviates symptoms of endometriosis and fibroids.
• Offers convenient monthly dosing.
• Helps manage precocious puberty.
• Improves quality of life in chronic conditions.

Side Effects

• Hot flashes
• Sweating
• Fatigue
• Headache
• Injection site reactions
• Bone pain
• Muscle weakness
• Mood changes
• Decreased libido
• Nausea
• Vomiting
• Weight gain

Safety Measures

• Alcohol - Alcohol consumption may exacerbate hot flashes and other side effects; use with caution.
• Pregnancy - Contraindicated in pregnancy due to its hormonal effects and potential harm to the fetus.
• Breastfeeding - Not recommended during breastfeeding as it may affect hormone levels and pass into breast milk.
• Liver - Use with caution in patients with severe liver impairment; monitoring may be required.
• Kidney - Generally no dose adjustment needed for kidney impairment, but caution is advised in severe cases.
• Lung - No specific precautions for lung conditions are typically required.

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