TRIPTY INJ 11.25 MG 1'S

About

Triptorelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH), designed to act as a potent and sustained inhibitor of gonadotropin secretion. Upon initial administration, it causes a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH), often referred to as a 'flare-up' effect. However, with continuous administration, it leads to a profound downregulation of pituitary GnRH receptors, effectively desensitizing the pituitary gland. This sustained suppression results in a significant reduction in gonadal steroid production, achieving a state of medical castration. Triptorelin is primarily utilized in the management of various hormone-sensitive conditions where the suppression of sex hormones, such as testosterone in men and estrogen in women, is therapeutically beneficial. Its long-acting formulations allow for less frequent dosing, improving patient adherence and convenience in chronic treatment regimens.

Uses

• Prostate cancer (hormone-dependent)
• Endometriosis
• Uterine fibroids
• Precocious puberty

Directions For Use

Administer intramuscularly as directed by a healthcare professional. Ensure proper aseptic technique.

Benefits

• Reduces testosterone levels in men
• Suppresses estrogen levels in women
• Alleviates symptoms of endometriosis
• Shrinks uterine fibroids
• Delays puberty progression
• Long-acting formulation reduces frequency of injections

Side Effects

• Hot flashes
• Sweating
• Headache
• Fatigue
• Injection site reactions
• Bone density loss (long-term)
• Mood changes
• Nausea
• Vaginal dryness (women)
• Erectile dysfunction (men)
• Breast tenderness
• Weight changes

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol may exacerbate hot flashes.
• Pregnancy - Contraindicated in pregnancy due to potential harm to the fetus.
• Breastfeeding - Not recommended during breastfeeding as it may suppress lactation and potential harm to infant.
• Liver - Use with caution in patients with severe liver impairment; dose adjustment may be necessary.
• Kidney - Use with caution in patients with severe kidney impairment; dose adjustment may be necessary.
• Lung - No specific precautions for lung conditions.

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