About

Chloramphenicol, marketed as Paraxin, is a potent broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Its mechanism of action makes it effective against a wide array of Gram-positive and Gram-negative bacteria, including anaerobes and some atypical organisms. Due to its potential for severe adverse effects, particularly bone marrow suppression, chloramphenicol is typically reserved for serious infections where other, less toxic antibiotics are ineffective or contraindicated. It is particularly valuable in treating life-threatening conditions such as bacterial meningitis, typhoid fever, and rickettsial infections, where its ability to penetrate various body compartments, including the central nervous system, is advantageous. Its use requires careful monitoring and a thorough risk-benefit assessment by a healthcare professional.

Uses

Treatment of bacterial meningitis.
Management of typhoid fever.
Therapy for rickettsial infections.
Treatment of severe anaerobic infections.

Directions For Use

Take one tablet orally with water, usually 3-4 times daily, or as prescribed by a physician. Complete the full course of medication even if symptoms improve.

Benefits

Broad spectrum of antibacterial activity.
Effective against many resistant bacterial strains.
Excellent penetration into the central nervous system.
Available in oral formulation for convenience.
Useful in severe, life-threatening infections.
Effective against intracellular pathogens.

Side Effects

Bone marrow suppression (aplastic anemia).
Dose-related bone marrow depression.
Gray baby syndrome (in neonates).
Optic neuritis.
Peripheral neuropathy.
Nausea.
Vomiting.
Diarrhea.
Stomatitis.
Glossitis.
Headache.
Fever.

Safety Measures

Alcohol - Avoid alcohol as it may exacerbate gastrointestinal side effects and potentially interact with drug metabolism, increasing toxicity.
Pregnancy - Generally contraindicated due to the risk of Gray baby syndrome in the newborn, especially in late pregnancy. Use only if no safer alternative exists and benefits outweigh risks.
Breastfeeding - Contraindicated due to excretion into breast milk and the risk of Gray baby syndrome or bone marrow suppression in the infant.
Liver - Use with extreme caution in liver impairment as it is extensively metabolized by the liver; dosage adjustment and close monitoring are necessary.
Kidney - Use with caution in renal impairment; dosage adjustment may be required, especially for the active metabolite, to prevent accumulation and toxicity.
Lung - No specific contraindications, but monitor for signs of pulmonary toxicity in prolonged use, though rare.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.

Shipping & Location