PENOGAB SR

About

Gabapentin is an anticonvulsant and neuropathic pain agent primarily used to manage postherpetic neuralgia and as adjunctive therapy for partial seizures. While structurally related to the neurotransmitter GABA, its mechanism of action does not involve direct binding to GABA receptors. Instead, it is believed to exert its effects by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This interaction reduces the influx of calcium into presynaptic nerve terminals, thereby decreasing the release of excitatory neurotransmitters. This action helps to stabilize neuronal membranes and reduce abnormal electrical activity in the brain, making it effective in managing certain types of seizures and alleviating neuropathic pain. The sustained-release (SR) formulation is designed to provide a more consistent therapeutic effect over an extended period, allowing for less frequent dosing, which can significantly improve patient adherence and maintain more stable plasma concentrations throughout the day.

Uses

• Management of postherpetic neuralgia.
• Adjunctive therapy in partial seizures.
• Treatment of neuropathic pain.
• Restless legs syndrome.

Directions For Use

Take this medication orally with or without food, as directed by your doctor. Swallow the tablet whole; do not crush or chew.

Benefits

• Effective in reducing neuropathic pain.
• Helps control certain types of seizures.
• Sustained-release formulation for convenient dosing.
• Generally well-tolerated.
• Can improve sleep quality in some patients.
• Non-addictive compared to some pain medications.

Side Effects

• Dizziness
• Drowsiness
• Fatigue
• Ataxia (loss of coordination)
• Peripheral edema
• Nausea
• Vomiting
• Diarrhea
• Weight gain
• Blurred vision
• Tremor
• Dry mouth

Safety Measures

• Alcohol - Avoid alcohol consumption as it can increase central nervous system side effects like dizziness and drowsiness.
• Pregnancy - Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
• Breastfeeding - Gabapentin passes into breast milk. Use with caution and monitor the infant for drowsiness or feeding difficulties.
• Liver - Generally safe for use in patients with liver conditions; no dose adjustment typically required.
• Kidney - Dose adjustment is necessary for patients with impaired kidney function to prevent accumulation and toxicity.
• Lung - Generally safe for use in patients with lung conditions; no specific precautions are usually needed.

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