POSOXIL - GR TAB 10'S

About

POSOXIL - GR TAB 10'S, likely containing Posaconazole, is a potent triazole antifungal agent used for the treatment and prophylaxis of invasive fungal infections. It works by inhibiting the enzyme lanosterol 14α-demethylase, which is essential for ergosterol synthesis in fungal cell membranes. This disruption leads to increased fungal cell membrane permeability and ultimately, fungal cell death. Its broad spectrum of activity covers a wide range of fungi, including yeasts and molds, making it particularly valuable against infections caused by Aspergillus, Candida, and Mucorales species, which can be life-threatening in immunocompromised patients.

The gastro-resistant (GR) formulation is designed to optimize absorption and bioavailability, ensuring consistent drug levels in the body. It is often prescribed for patients who are at high risk of developing invasive fungal infections, such as those undergoing chemotherapy, hematopoietic stem cell transplantation, or with severe graft-versus-host disease. Its efficacy in both treatment and prevention underscores its importance in clinical practice for managing complex mycotic diseases.

Uses

• Treatment of invasive aspergillosis
• Management of invasive candidiasis
• Therapy for mucormycosis
• Prophylaxis of invasive fungal infections in high-risk patients

Directions For Use

Take orally with a full meal or a liquid nutritional supplement to enhance absorption, as directed by your physician.

Benefits

• Broad spectrum of antifungal activity
• Effective against resistant fungal strains
• Oral formulation offers convenience
• Crucial for prophylaxis in immunocompromised patients
• Improves outcomes in severe fungal infections
• Reduced mortality in high-risk patient populations

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Elevated liver enzymes
• Skin rash
• Fatigue
• Hypokalemia
• Hypertension
• QT prolongation

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to the potential for increased liver toxicity and gastrointestinal side effects.
• Pregnancy - Avoid use during pregnancy unless the potential benefit justifies the potential risk to the fetus. It has shown teratogenic effects in animal studies.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it is excreted in human milk and could cause serious adverse reactions in the infant.
• Liver - Contraindicated in severe hepatic impairment. Monitor liver function tests closely during treatment, and dose adjustment may be necessary in moderate impairment.
• Kidney - Generally, no dose adjustment is needed for the oral formulation in patients with renal impairment. Monitor for adverse effects.
• Lung - Used for pulmonary fungal infections. Monitor for drug interactions and potential adverse effects, especially in patients with pre-existing lung conditions.

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