About
Remogliflozin etabonate is a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor that acts by preventing the reabsorption of glucose in the kidneys, leading to its excretion in the urine and a subsequent reduction in blood glucose levels. Metformin, a biguanide, works primarily by decreasing glucose production in the liver, reducing glucose absorption from the intestines, and improving the body's sensitivity to insulin. This combination therapy offers a comprehensive and synergistic approach to managing type 2 diabetes mellitus. By addressing multiple pathways involved in glucose regulation, it effectively lowers HbA1c, improves glycemic control, and can contribute to modest weight reduction. It is prescribed as an adjunct to diet and exercise for patients requiring enhanced blood sugar management and to achieve optimal metabolic control.
Uses
- Treatment of type 2 diabetes mellitus.
- Improvement of glycemic control.
- Used as an adjunct to diet and exercise.
- Reduction of HbA1c levels.
Directions For Use
Take orally with meals, as directed by your physician, usually once or twice daily, to minimize gastrointestinal side effects.
Benefits
- Significant reduction in blood glucose.
- Potential for modest weight loss.
- Enhanced insulin sensitivity.
- Lower risk of hypoglycemia (compared to insulin or sulfonylureas).
- Dual mechanism of action for comprehensive control.
- Improved overall metabolic health.
Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Vomiting
- Urinary tract infections (UTIs)
- Genital yeast infections
- Increased urination
- Headache
- Dizziness
- Lactic acidosis (rare, but serious with metformin)
- Vitamin B12 deficiency (long-term metformin use)
- Ketoacidosis (rare, with SGLT2 inhibitors)
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it significantly increases the risk of lactic acidosis, a serious side effect of metformin.
- Pregnancy - Generally not recommended during pregnancy. Consult a doctor to weigh the benefits against potential risks to the fetus.
- Breastfeeding - Metformin is excreted in breast milk; SGLT2 inhibitors may also be. Consult a doctor to assess risks and benefits for the infant.
- Liver - Use with caution in patients with liver impairment due to increased risk of lactic acidosis with metformin.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment is necessary for moderate impairment.
- Lung - Generally safe, but severe respiratory failure can increase the risk of lactic acidosis due to metformin.
Disclaimer
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