About
Remogliflozin etabonate is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by increasing the excretion of glucose in the urine, thereby lowering blood glucose levels. Metformin is a biguanide that primarily reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity. This combination therapy provides a powerful and complementary approach to managing type 2 diabetes mellitus. By targeting different pathways of glucose metabolism, it offers comprehensive glycemic control, helps reduce HbA1c levels, and can contribute to modest weight loss. It is used as an adjunct to diet and exercise for patients requiring improved blood sugar management and to mitigate the risks associated with uncontrolled diabetes.
Uses
- Treatment of type 2 diabetes mellitus.
- Improvement of glycemic control.
- Used as an adjunct to diet and exercise.
- Reduction of HbA1c levels.
Directions For Use
Take orally with meals, as directed by your physician, usually once or twice daily, to minimize gastrointestinal side effects.
Benefits
- Potent blood glucose reduction.
- Potential for weight loss.
- Improved insulin sensitivity.
- Reduced risk of hypoglycemia (compared to some other agents).
- Dual mechanism of action.
- Comprehensive glycemic control.
Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Vomiting
- Urinary tract infections (UTIs)
- Genital yeast infections
- Increased urination
- Headache
- Dizziness
- Lactic acidosis (rare, but serious with metformin)
- Vitamin B12 deficiency (long-term metformin use)
- Ketoacidosis (rare, with SGLT2 inhibitors)
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it significantly increases the risk of lactic acidosis, a serious side effect of metformin.
- Pregnancy - Generally not recommended during pregnancy. Consult a doctor to weigh the benefits against potential risks to the fetus.
- Breastfeeding - Metformin is excreted in breast milk; SGLT2 inhibitors may also be. Consult a doctor to assess risks and benefits for the infant.
- Liver - Use with caution in patients with liver impairment due to increased risk of lactic acidosis with metformin.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment is necessary for moderate impairment.
- Lung - Generally safe, but severe respiratory failure can increase the risk of lactic acidosis due to metformin.
Disclaimer
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