ROZAT CV 10 S

About

ROZAT CV is a combination medication containing Rosuvastatin and Clopidogrel. Rosuvastatin is a HMG-CoA reductase inhibitor (statin) that reduces cholesterol synthesis in the liver, leading to a decrease in LDL-C, total cholesterol, and triglycerides, while increasing HDL-C. Clopidogrel is an antiplatelet agent that selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, thereby preventing platelet aggregation and thrombus formation. This combination is designed for patients at high risk of cardiovascular events.

The synergistic action of these two drugs provides comprehensive protection against atherosclerosis and thrombotic events. It is typically prescribed for patients who have recently experienced an acute coronary syndrome (ACS), myocardial infarction (MI), or stroke, or those undergoing percutaneous coronary intervention (PCI) to prevent further cardiovascular complications. Regular monitoring of lipid profiles and bleeding risk is crucial during treatment.

Uses

• Prevention of atherosclerotic events in high-risk patients.
• Following acute coronary syndrome (ACS).
• After percutaneous coronary intervention (PCI).
• Secondary prevention of myocardial infarction and stroke.

Directions For Use

Take orally once daily with water, with or without food, as directed by your physician. Do not crush or chew.

Benefits

• Significantly lowers LDL-C and total cholesterol.
• Reduces the risk of heart attack and stroke.
• Prevents blood clot formation.
• Provides dual cardiovascular protection.
• Improves lipid profile.
• Convenient once-daily dosing.

Side Effects

• Muscle pain (myalgia)
• Headache
• Nausea
• Abdominal pain
• Diarrhea
• Bleeding (e.g., nosebleeds, bruising)
• Fatigue
• Dizziness
• Rash
• Indigestion
• Joint pain (arthralgia)
• Increased liver enzymes

Safety Measures

• Alcohol - Limit alcohol intake as it can increase the risk of liver problems with rosuvastatin and may increase bleeding risk with clopidogrel.
• Pregnancy - Contraindicated during pregnancy due to potential fetal harm from rosuvastatin.
• Breastfeeding - Contraindicated during breastfeeding as both components can pass into breast milk and may harm the infant.
• Liver - Contraindicated in active liver disease or unexplained persistent elevations of serum transaminases. Use with caution in liver impairment.
• Kidney - Use with caution in patients with severe renal impairment; dosage adjustments may be necessary for rosuvastatin.
• Lung - Generally safe, but rare cases of interstitial lung disease have been reported with statins. Monitor for respiratory symptoms.

Disclaimer

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